Molecular structure of Lyso-PAF C-16, CAS Number: 52691-62-0
Lyso-PAF C-16 (CAS 52691-62-0)
Application:
Lyso-PAF C-16 is an inactive platelet activating factor (PAF)
CAS Number:
52691-62-0
Molecular Weight:
481.7
Molecular Formula:
C24H52NO6P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF) (sc-200516) and has been used to study PAF synthesis. PAF is known to activate inflammatory cells and platelets. It has been reported that the activity of a coenzyme A-independent transacylase generates lyso-PAF, which can be turned into PAF after it is acetylated. Research suggest that both PAF and lyso-PAF may have antimicrobial properties in vitro, against gram-positive bacteria.
Lyso-PAF C-16 (CAS 52691-62-0) References
- Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. | Kosaka, T., et al. 2000. Clin Chim Acta. 296: 151-61. PMID: 10807978
- Similar effects of ether phospholipids, PAF and lyso-PAF on the Ca(2+)-ATPase activity of rat brain synaptosomes and leukocyte membranes. | Grosman, N. 2001. Int Immunopharmacol. 1: 1321-9. PMID: 11460312
- Receptor-dependent metabolism of platelet-activating factor in murine macrophages. | Ohshima, N., et al. 2002. J Biol Chem. 277: 9722-7. PMID: 11786559
- Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | Steel, HC., et al. 2002. APMIS. 110: 158-64. PMID: 12064871
- A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. | Uemura, Y., et al. 1991. J Biol Chem. 266: 8268-72. PMID: 2022643
- Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. | Sanz-Vicente, I., et al. 2017. Anal Biochem. 519: 30-37. PMID: 27956151
- Direct Growth Inhibitory Effect of Platelet Activating Factor C-16 and Its Structural Analogs on Mycobacteria. | Riaz, MS., et al. 2018. Front Microbiol. 9: 1903. PMID: 30258409
- Serum metabolomics analysis of mice that received repeated airway exposure to a water-soluble PM2.5 extract. | Zhao, C., et al. 2019. Ecotoxicol Environ Saf. 168: 102-109. PMID: 30384157
- Human plasma platelet-activating factor acetylhydrolase. Purification and properties. | Stafforini, DM., et al. 1987. J Biol Chem. 262: 4223-30. PMID: 3558407
- Metabolism of platelet-activating factor by rat alveolar macrophages: lyso-PAF as an obligatory intermediate in the formation of alkylarachidonoyl glycerophosphocholine species. | Robinson, M. and Snyder, F. 1985. Biochim Biophys Acta. 837: 52-6. PMID: 4052436
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lyso-PAF C-16, 1 mg | sc-201011B | 1 mg | $42.00 | |||
Lyso-PAF C-16, 5 mg | sc-201011 | 5 mg | $84.00 | |||
Lyso-PAF C-16, 10 mg | sc-201011C | 10 mg | $147.00 | |||
Lyso-PAF C-16, 25 mg | sc-201011A | 25 mg | $294.00 |