Date published: 2025-10-18

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Lysinonorleucine (CAS 25612-46-8)

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Application:
Lysinonorleucine is A Lysine and hydroxylysine derivative
CAS Number:
25612-46-8
Molecular Weight:
275.34
Molecular Formula:
C12H25N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lysinonorleucine is a dipeptide with application in biochemical research due to its role as a biomarker for protein damage, particularly in the study of protein cross-linking and degradation. It is used to assess the extent of protein oxidation and cross-linking events under various experimental conditions, including oxidative stress and aging studies in cellular and tissue systems. The presence of lysinonorleucine in proteins is indicative of advanced glycation end products (AGEs), which researchers analyze to understand the aging process and the long-term effects of hyperglycemia in biological systems. Additionally, lysinonorleucine is involved in the elucidation of pathways related to protein turnover and post-translational modifications, providing insights into cellular mechanisms for maintaining protein integrity. Its quantification is also essential in the field of proteomics, where it aids in the characterization of complex protein mixtures and the identification of novel protein-protein interactions.


Lysinonorleucine (CAS 25612-46-8) References

  1. Effect of hyper- and microgravity on collagen post-translational controls of MC3T3-E1 osteoblasts.  |  Saito, M., et al. 2003. J Bone Miner Res. 18: 1695-705. PMID: 12968680
  2. Intensity-related differences in collagen post-translational modification in MC3T3-E1 osteoblasts after exposure to low- and high-intensity pulsed ultrasound.  |  Saito, M., et al. 2004. Bone. 35: 644-55. PMID: 15336600
  3. A model two-component system for studying the architecture of elastin assembly in vitro.  |  Mithieux, SM., et al. 2005. J Struct Biol. 149: 282-9. PMID: 15721582
  4. Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture.  |  Saito, M., et al. 2006. Osteoporos Int. 17: 986-95. PMID: 16552468
  5. Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats.  |  Saito, M., et al. 2006. Osteoporos Int. 17: 1514-23. PMID: 16770520
  6. Elastin and elastin-associated-protein of porcine aorta and lung.  |  Richmond, VL. 1990. Connect Tissue Res. 25: 131-7. PMID: 2175693
  7. Collagen cross-link synthesis in cultured vascular endothelium.  |  Levene, CI., et al. 1989. Br J Exp Pathol. 70: 621-6. PMID: 2605112
  8. An Evaluation of Lysyl Oxidase-Derived Cross-Linking in Keratoconus by Liquid Chromatography/Mass Spectrometry.  |  Takaoka, A., et al. 2016. Invest Ophthalmol Vis Sci. 57: 126-36. PMID: 26780316
  9. Elastin is heterogeneously cross-linked.  |  Schräder, CU., et al. 2018. J Biol Chem. 293: 15107-15119. PMID: 30108173
  10. Allysine modifications perturb tropoelastin structure and mobility on a local and global scale.  |  Ozsvar, J., et al. 2019. Matrix Biol Plus. 2: 100002. PMID: 33543005
  11. Nucleosides and amino acids, isolated from Cordyceps sinensis, protected against cyclophosphamide-induced myelosuppression in mice.  |  Zhang, Y., et al. 2022. Nat Prod Res. 36: 6056-6059. PMID: 35188001
  12. Elastase digestion and biochemical analysis of the elastin from an elastofibroma.  |  Nakamura, Y., et al. 1986. Cancer. 58: 1070-5. PMID: 3637115
  13. Synthesis of lysinonorleucine and mass spectrometric analysis of lysinonorleucine and merodesmosine in bovine ligament and eggshell membrane.  |  Oishi, K., et al. 2023. Arch Biochem Biophys. 740: 109585. PMID: 37001748
  14. Histone H1 is a substrate for lysyl oxidase and contains endogenous sodium borotritide-reducible residues.  |  Kagan, HM., et al. 1983. Biochem Biophys Res Commun. 115: 186-92. PMID: 6137217
  15. Single-column high-performance liquid chromatographic-fluorescence detection of immature, mature, and senescent cross-links of collagen.  |  Saito, M., et al. 1997. Anal Biochem. 253: 26-32. PMID: 9356137

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lysinonorleucine, 5 mg

sc-207837
5 mg
$337.00

Hi, I need Lysinonorleucine for my experiment. Can you provide me the quote? Regards, Santosh 

Asked by: Santosh
Thank you for your question. Please contact our Customer Care Department to request a quote for this chemical, Lysinonorleucine (CAS 25612-46-8): sc-207837. Please call our U.S. Headquarters by phone at (800) 457-3801 option 1, email customercare@scbt.com, or use our live chat!
Answered by: Technical Support
Date published: 2017-12-01
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Rated 5 out of 5 by from Lysinonorleucinewas utilized as a enzymatic crossLysinonorleucinewas utilized as a enzymatic cross-link, in many articles. -SCBT Publication Review
Date published: 2015-02-15
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Lysinonorleucine is rated 5.0 out of 5 by 1.
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