Date published: 2025-11-1

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Lymecycline (CAS 992-21-2)

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Alternate Names:
Mucomycin
Application:
Lymecycline is a semi-synthetic antibiotic related to Tetracycline (sc-205858)
CAS Number:
992-21-2
Molecular Weight:
602.63
Molecular Formula:
C29H38N4O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lymecycline, a tetracycline, is frequently used in the field of biochemistry for studying gene expression and protein synthesis at the cellular level. In research, it is often employed to probe the role of tetracyclines in inhibiting bacterial ribosomes, thereby preventing the addition of amino acids to growing peptide chains. This action makes it a useful tool in the study of bacterial resistance mechanisms and the identification of potential targets for new antibacterial compounds. Additionally, lymecycline′s interactions with ribosomal subunits offer a window into the fundamental processes of translation in prokaryotes. Its use in research applications also includes examining its environmental impact, particularly its role in the development of antibiotic resistance genes in natural bacterial communities, which is a growing concern in environmental toxicology.


Lymecycline (CAS 992-21-2) References

  1. Successful treatment of Melkersson-Rosenthal Syndrome with lymecycline.  |  Pigozzi, B., et al. 2004. Eur J Dermatol. 14: 166-7. PMID: 15246942
  2. Hidradenitis suppurativa: A practical review of possible medical treatments based on over 350 hidradenitis patients.  |  Scheinfeld, N. 2013. Dermatol Online J. 19: 1. PMID: 24021361
  3. Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation.  |  Costa, A., et al. 2013. Dermatol Res Pract. 2013: 120475. PMID: 24191156
  4. Isotretinoin and lymecycline treatments modify the skin microbiota in acne.  |  Kelhälä, HL., et al. 2018. Exp Dermatol. 27: 30-36. PMID: 28636791
  5. Lymecycline reverses acquired EGFR-TKI resistance in non-small-cell lung cancer by targeting GRB2.  |  Chen, Y., et al. 2020. Pharmacol Res. 159: 105007. PMID: 32561477
  6. Lymecycline vs. clindamycin plus rifampicin in hidradenitis suppurativa treatment: clinical and ultrasonography evaluation.  |  Caposiena Caro, RD., et al. 2021. Clin Exp Dermatol. 46: 96-102. PMID: 32683727
  7. Lymecycline as a treatment option for dissecting cellulitis and folliculitis decalvans.  |  Melo, DF., et al. 2020. Dermatol Ther. 33: e14051. PMID: 32705744
  8. Treatment of hidradenitis suppurativa with tetracycline, doxycycline, or lymecycline: a prospective study.  |  Jørgensen, AR., et al. 2021. Int J Dermatol. 60: 785-791. PMID: 33660281
  9. An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris.  |  Tolino, E., et al. 2021. J Clin Aesthet Dermatol. 14: 56-58. PMID: 34188751
  10. Acne Fulminans Induced by Lymecycline in a Patient with Hidradenitis Suppurativa: A Case Report.  |  Trave, I., et al. 2022. Case Rep Dermatol. 14: 112-116. PMID: 35702372
  11. Completion of the impurity profile of lymecycline: Formal identification of impurities E and F.  |  Billié, S., et al. 2022. J Pharm Biomed Anal. 220: 114993. PMID: 36007309
  12. Comparative bioavailability of tetracycline and lymecycline.  |  Sjölin-Forsberg, G. and Hermansson, J. 1984. Br J Clin Pharmacol. 18: 529-33. PMID: 6487493
  13. Effects of lymecycline on Mycoplasma pulmonis-induced arthritis in mice.  |  Taylor, G., et al. 1978. Br J Exp Pathol. 59: 204-12. PMID: 656320

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lymecycline, 1 mg

sc-397567E
1 mg
$145.00

Lymecycline, 5 mg

sc-397567
5 mg
$230.00

Lymecycline, 10 mg

sc-397567A
10 mg
$340.00

Lymecycline, 50 mg

sc-397567B
50 mg
$655.00

Lymecycline, 100 mg

sc-397567C
100 mg
$885.00

Lymecycline, 250 mg

sc-397567D
250 mg
$1775.00