Lyl-1 Antibody (C-4): sc-374164
- Lyl-1 Antibody (C-4) is a mouse monoclonal IgG2b κ Lyl-1 antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 188-267 mapping at the C-terminus of Lyl-1 of human origin
- Lyl-1 Antibody (C-4) is recommended for detection of Lyl-1 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Lyl-1 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-374164 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Lyl-1 Antibody (C-4). This work is in progress.
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SEE ALSO...
Lyl-1 Antibody (C-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects Lyl-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Lyl-1 (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Lyl-1, also known as lymphoblastic leukemia-derived sequence 1, plays a crucial role in regulating hematopoiesis and is primarily located in the nucleus, where Lyl-1 interacts with E2α proteins to form heterodimeric complexes that exhibit unique DNA-binding properties. This nuclear localization enables Lyl-1 to influence gene expression patterns critical for T cell development and function. Aberrations involving Lyl-1 are associated with T cell acute lymphoblastic leukemia (T-ALL), highlighting Lyl-1′s relevance in oncogenic processes. Lyl-1 belongs to a family of basic helix-loop-helix (bHLH) transcription factors, including TAL1 and TAL2, which are implicated in various hematological malignancies. Using anti-Lyl-1 antibody (C-4) in research can provide valuable insights into the molecular mechanisms underlying T cell development and the pathogenesis of related leukemias.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Lyl-1 Antibody (C-4) References:
- T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein. | Goldfarb, AN., et al. 1992. Blood. 80: 2858-66. PMID: 1450410
- Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. | Kuo, SS., et al. 1991. Oncogene. 6: 961-8. PMID: 2067848
- lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. | Mellentin, JD., et al. 1989. Cell. 58: 77-83. PMID: 2752424
- Chromosomal translocation involving the beta T cell receptor gene in acute leukemia. | Cleary, ML., et al. 1988. J Exp Med. 167: 682-7. PMID: 3162254
- Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. | Wadman, I., et al. 1994. EMBO J. 13: 4831-9. PMID: 7957052
- Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. | Trask, B., et al. 1993. Genomics. 15: 133-45. PMID: 8432525
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lyl-1 Antibody (C-4) | sc-374164 | 200 µg/ml | $322.00 | |||
Lyl-1 Antibody (C-4) X | sc-374164 X | 200 µg/0.1 ml | $322.00 | |||
Lyl-1 Antibody (C-4) AC | sc-374164 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Lyl-1 Antibody (C-4) HRP | sc-374164 HRP | 200 µg/ml | $322.00 | |||
Lyl-1 Antibody (C-4) FITC | sc-374164 FITC | 200 µg/ml | $336.00 | |||
Lyl-1 Antibody (C-4) PE | sc-374164 PE | 200 µg/ml | $349.00 | |||
Lyl-1 Antibody (C-4) Alexa Fluor® 488 | sc-374164 AF488 | 200 µg/ml | $364.00 | |||
Lyl-1 Antibody (C-4) Alexa Fluor® 546 | sc-374164 AF546 | 200 µg/ml | $364.00 | |||
Lyl-1 Antibody (C-4) Alexa Fluor® 594 | sc-374164 AF594 | 200 µg/ml | $364.00 | |||
Lyl-1 Antibody (C-4) Alexa Fluor® 647 | sc-374164 AF647 | 200 µg/ml | $364.00 | |||
Lyl-1 Antibody (C-4) Alexa Fluor® 680 | sc-374164 AF680 | 200 µg/ml | $364.00 | |||
Lyl-1 Antibody (C-4) Alexa Fluor® 790 | sc-374164 AF790 | 200 µg/ml | $364.00 |