LY404039 is a potent agonist of recombinant human mGluR-2, mGluR-3 receptors with Ki of 149 nM, and 92 nM respectively. LY404039 suppresses electrically evoked excitatory activity in the striatum, and serotonin-induced L-glutamate release in the prefrontal cortex. LY404039 could modulate glutamatergic activity in limbic and forebrain areas relevant to psychiatric disorders and may be devoid of negative side effects associated with current antipsychotics and anxiolytics.
Soluble in 30% propylene glycol, 5% Tween 80, 65% D5W (30 mg/ml at 25 °C), DMSO (1 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (< 1 mg/ml at 25 °C).
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