Molecular structure of LY3009120, CAS Number: 1454682-72-4
LY3009120 (CAS 1454682-72-4)
CAS Number:
1454682-72-4
Molecular Weight:
424.51
Molecular Formula:
C23H29FN6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LY3009120 (CAS 1454682-72-4) References
- Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. | Peng, SB., et al. 2015. Cancer Cell. 28: 384-98. PMID: 26343583
- LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. | Vakana, E., et al. 2017. Oncotarget. 8: 9251-9266. PMID: 27999210
- Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer. | Wei, WJ., et al. 2017. Theranostics. 7: 987-1001. PMID: 28382170
- A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer. | Zhao, X., et al. 2017. Cancer Lett. 402: 61-70. PMID: 28576749
- RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1. | Chen, SH., et al. 2018. Oncogene. 37: 821-832. PMID: 29059158
- LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-α, PPAR-γ, STAT‑3, FAS, ACC, perilipin A, and AMPK. | Yang, SM., et al. 2018. Int J Mol Med. 42: 3477-3484. PMID: 30272260
- A pan-RAF inhibitor LY3009120 inhibits necroptosis by preventing phosphorylation of RIPK1 and alleviates dextran sulfate sodium-induced colitis. | Zhang, C., et al. 2019. Clin Sci (Lond). 133: 919-932. PMID: 30944150
- Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation. | Miyauchi, S., et al. 2020. Anticancer Res. 40: 2667-2673. PMID: 32366411
- Pan-RAF inhibitor LY3009120 is highly synergistic with low-dose cytarabine, but not azacitidine, in acute myeloid leukemia with RAS mutations. | Park, J., et al. 2021. Oncol Lett. 22: 745. PMID: 34539849
- Cross-Species Comparison of the Pan-RAF Inhibitor LY3009120's Anti-Tumor Effects in Equine, Canine, and Human Malignant Melanoma Cell Lines. | Gao, Y., et al. 2024. Genes (Basel). 15: PMID: 38397192
Inhibitor of:
Brk, MAGE-C3, mEH, MEK kinase-2, Raf-1, raf-A, Raf-B, RASAL1, RasGRP2, and RSPRY1.Activator of:
RAO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY3009120, 5 mg | sc-507538 | 5 mg | $125.00 |