Molecular structure of LY223982, CAS Number: 117423-74-2
LY223982 (CAS 117423-74-2)
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Alternate Names:
SKF 107324
Application:
LY223982 is a potent P2Y7 (BLT1) receptor antagonist
CAS Number:
117423-74-2
Purity:
≥95%
Molecular Weight:
502.6
Molecular Formula:
C30H30O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY223982 is a potent P2Y7 (BLT1) receptor antagonist and benzophenone dicarboxylic acid derivative. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM. LY223982 inhibits the LTB4-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively.
LY223982 (CAS 117423-74-2) References
- Activation of leukotriene synthesis in human neutrophils by exogenous arachidonic acid: inhibition by adenosine A(2a) receptor agonists and crucial role of autocrine activation by leukotriene B(4). | Surette, ME., et al. 1999. Mol Pharmacol. 56: 1055-62. PMID: 10531413
- LTA(4)-derived 5-oxo-eicosatetraenoic acid: pH-dependent formation and interaction with the LTB(4) receptor of human polymorphonuclear leukocytes. | Falgueyret, J. and Riendeau, D. 2000. Biochim Biophys Acta. 1484: 51-8. PMID: 10685030
- A rapid microtiter plate method for the detection of lysozyme release from human neutrophils. | Moreira-Ludewig, R. and Healy, CT. 1992. J Pharmacol Toxicol Methods. 27: 95-100. PMID: 1317227
- Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. | Jackson, WT., et al. 1992. J Pharmacol Exp Ther. 263: 1009-14. PMID: 1335049
- Technique for quantification of LTB4-induced changes in peripheral granulocyte counts in vivo in the rabbit. | Griswold, DE., et al. 1991. J Pharmacol Methods. 25: 319-28. PMID: 1653383
- CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a. | Vaivoda, R., et al. 2015. J Immunol Res. 2015: 250456. PMID: 26613087
- Endocervical and Neutrophil Lipoxygenases Coordinate Neutrophil Transepithelial Migration to Neisseria gonorrhoeae. | Stevens, JS., et al. 2018. J Infect Dis. 218: 1663-1674. PMID: 29905822
- The LTB4-BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis. | Subramanian, BC., et al. 2018. J Cell Sci. 131: PMID: 30158177
- The LTB4-BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation. | Subramanian, BC., et al. 2020. J Cell Biol. 219: PMID: 32854115
- Exosomes mediate LTB4 release during neutrophil chemotaxis. | Majumdar, R., et al. 2021. PLoS Biol. 19: e3001271. PMID: 34232954
- Nickel-Catalyzed Stereoselective Alkenylation of Ketones Mediated by Hydrazine. | Xia, S., et al. 2022. JACS Au. 2: 1929-1934. PMID: 36032538
- Stereochemical analysis and biological activity of 3-hydroxy-leukotriene B4: a metabolite from ethanol-treated rat hepatocytes. | Wheelan, P., et al. 1994. J Pharmacol Exp Ther. 271: 1514-9. PMID: 7996465
- Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: specificity of different chemotactic agents. | Rainger, GE., et al. 1998. Blood. 92: 4819-27. PMID: 9845549
Inhibitor of:
LTB4R2, and P2Y7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY223982, 1 mg | sc-221865 | 1 mg | $43.00 | |||
LY223982, 5 mg | sc-221865A | 5 mg | $198.00 |