Date published: 2026-5-13

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LY 78335 (CAS 39959-66-5)

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Alternate Names:
2,3-Dichloro-α-methylbenzylamine hydrochloride
Application:
LY 78335 is a selective inhibitor of phenylethanolamine-N-methyltransferase (PNMT)
CAS Number:
39959-66-5
Purity:
≥97%
Molecular Weight:
226.53
Molecular Formula:
C8H9Cl2N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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LY 78335 is a selective inhibitor of phenylethanolamine-N-methyltransferase (PNMT), an enzyme in the biosynthesis of epinephrine from norepinephrine. This specificity makes LY 78335 a significant compound in neurochemical research, as it allows for detailed study of the catecholamine pathway, which is integral to stress response and neurotransmission. Inhibition of PNMT by LY 78335 has been utilized to probe the regulatory mechanisms governing catecholamine production, offering insights into the physiological and potential pathophysiological roles of epinephrine. The selectivity of LY 78335 also aids in distinguishing the effects of epinephrine relative to other catecholamines, thereby refining our understanding of its function in both the central nervous system and peripheral organs.


LY 78335 (CAS 39959-66-5) References

  1. Tyrosine kinase effects on adrenoceptor-stimulated cyclic AMP accumulation in preoptic area and hypothalamus of female rats: modulation by estradiol.  |  Quesada, A. and Etgen, AM. 2000. Brain Res. 861: 117-25. PMID: 10751571
  2. Modulatory role of the epinergic system in the neuroendocrine-immune system function.  |  Giovambattista, A., et al. 2000. Neuroimmunomodulation. 8: 98-106. PMID: 10965235
  3. Role of adrenergic neuronal activity in the yawning induced by tacrine and NIK-247 in rats.  |  Kimura, H., et al. 1992. Pharmacol Biochem Behav. 43: 985-91. PMID: 1361995
  4. Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol.  |  Durcan, MJ., et al. 1990. Psychopharmacology (Berl). 101: 196-202. PMID: 2349361
  5. Neurotransmitter involvement in naloxone-induced stimulation of pulsatile LH release on day 8 of pregnancy in the rat.  |  Mallory, DS., et al. 1989. Brain Res Bull. 22: 1015-21. PMID: 2790494
  6. Catecholamine involvement in preovulatory LH release: reassessment of the role of epinephrine.  |  Kalra, SP. 1985. Neuroendocrinology. 40: 139-44. PMID: 4038787
  7. Evidence that norepinephrine and epinephrine systems mediate the stimulatory effects of ovarian hormones on luteinizing hormone and luteinizing hormone-releasing hormone.  |  Adler, BA., et al. 1983. Endocrinology. 113: 1431-8. PMID: 6352246
  8. Role of central epinephrine in regulation of anterior pituitary hormone secretion.  |  Terry, LC., et al. 1982. Peptides. 3: 311-8. PMID: 6750566
  9. Regulation of episodic growth hormone secretion by the central epinephrine system. Studies in the chronically cannulated rat.  |  Terry, LC., et al. 1982. J Clin Invest. 69: 104-12. PMID: 7054231
  10. Epinephrine synthesis inhibitors block naloxone-induced LH release.  |  Kalra, SP. and Crowley, WR. 1982. Endocrinology. 111: 1403-5. PMID: 7117202
  11. Effects of putative dopamine D3 receptor agonists, 7-OH-DPAT, and quinpirole, on yawning, stereotypy, and body temperature in rats.  |  Kurashima, M., et al. 1995. Pharmacol Biochem Behav. 52: 503-8. PMID: 8545466
  12. Yawning behavior for preclinical drug evaluation.  |  Furukawa, T. 1996. Methods Find Exp Clin Pharmacol. 18: 141-55. PMID: 8740246
  13. An anxiolytic action of oxytocin is enhanced by estrogen in the mouse.  |  McCarthy, MM., et al. 1996. Physiol Behav. 60: 1209-15. PMID: 8916173

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

LY 78335, 10 mg

sc-361248
10 mg
$260.00
US: Only available in the US

LY 78335, 50 mg

sc-361248A
50 mg
$1040.00
US: Only available in the US