Ly-6H Antibody (MN-7): sc-100285

Ly-6H Antibody (MN-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ly-6H protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Ly-6H antibody (MN-7) is available as a non-conjugated format. Ly-6H protein, also known as NMLY6, is a 140 amino acid lipid-anchored membrane protein that plays a crucial role in T lymphocyte activation, making Ly-6H essential for the adaptive immune response. Ly-6H protein is highly expressed in the brain, with lower levels found in the pancreas, testis, colon, and small intestine, indicating significant involvement in immune functions within the central nervous system. Unique expression patterns of Ly-6H during hematopoiesis, from multipotential stem cells to lineage-committed precursor cells, highlight Ly-6H protein′s importance in the development and differentiation of immune cells. Overexpression of Ly-6H in certain acute human leukemic cell lines, such as MOLT-3, suggests a potential role in carcinogenesis, making Ly-6H protein a valuable target for research in cancer biology.

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Ly-6H Antibody (MN-7) References:

1. Identification of mouse Ly6H and its expression in normal tissue.  |  Apostolopoulos, J., et al. 1999. Immunogenetics. 49: 987-90. PMID: 10501842
2. Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion.  |  Flanagan, K., et al. 2008. J Immunol. 180: 3874-81. PMID: 18322195
3. The LY-6 locus: a multigene family encoding phosphatidylinositol-anchored membrane proteins concerned with T-cell activation.  |  Rock, KL., et al. 1989. Immunol Rev. 111: 195-224. PMID: 2697681
4. Isolation of a murine Ly-6 cDNA reveals a new multigene family.  |  LeClair, KP., et al. 1986. EMBO J. 5: 3227-34. PMID: 3028776
5. Isolation and characterization of a new member of the human Ly6 gene family (LY6H).  |  Horie, M., et al. 1998. Genomics. 53: 365-8. PMID: 9799603

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ly-6H Antibody (MN-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Ly-6H Antibody (MN-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ly-6H Antibody (MN-7) Specifications

Alternate Product Name: Ly-6H

Product Clone Name: MN-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 26-141

Epitope Target: Ly-6H

Epitope Species: human

Product Reactivity/Detection: Ly-6H

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Ly-6H Antibody (MN-7): N/A