Molecular structure of LY 393558, CAS Number: 271780-64-4
LY 393558 (CAS 271780-64-4)
Application:
LY 393558 is a dual SR-1B/SR-1D antagonist
CAS Number:
271780-64-4
Purity:
≥98%
Molecular Weight:
546.68
Molecular Formula:
C26H31FN4O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 393558 is a dual SR-1B/SR-1D antagonist (pKB values are 9.05 and 8.98, respectively) and a serotonin re-uptake inhibitor (pIC50 = 8.48). LY 393558 has been shown to potently antagonize terminal autoreceptor activity in vitro and increase extracellular serotonin levels above those evoked by fluoxetine in vivo. It has also been shown to act as an antagonist at SR-2A and SR-2B (pKi values are 7.29 and 7.35, respectively).
LY 393558 (CAS 271780-64-4) References
Mitchell et al (2001) LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT1B/1D receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat. Eur.J.Pharmacol. 432 19. Pullar et al (2001) In vitro activity of LY393558, an inhibitor of the 5-hydroxytryptamine transporter with 5-HT(1B/1D/2) receptor antagonist properties. Eur.J.Pharmacol. 432 9. Morecroft et al (2005) Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries. J.Pharmacol.Exp.Ther. 313 539.Inhibitor of:
SR-1B, SR-1D, SR-2A, and SR-2B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 393558, 10 mg | sc-295369 | 10 mg | $185.00 | |||
LY 393558, 50 mg | sc-295369A | 50 mg | $772.00 |