LY 367385 (CAS 198419-91-9)
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LY 367385 functions as a selective antagonist of the metabotropic glutamate receptor subtype 1 (mGluR1). It exerts its action by binding to the allosteric site of the receptor, thereby inhibiting its activation by glutamate. This interaction prevents the downstream signaling cascade that is typically initiated by mGluR1 activation. Specifically, LY 367385 blocks the coupling of mGluR1 to G proteins, leading to a reduction in intracellular calcium levels and the inhibition of protein kinase C activity. By interfering with these cellular processes, LY 367385 ultimately modulates synaptic transmission and plasticity in the central nervous system. LY 367385 has neuroprotective effects in certain experimental models, potentially due to its ability to attenuate excitotoxicity and oxidative stress. LY 367385 plays a role in the regulation of glutamatergic neurotransmission and may have implications for understanding the pathophysiology of various neurological disorders.
LY 367385 (CAS 198419-91-9) References
- Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). | Chapman, AG., et al. 1999. Eur J Pharmacol. 368: 17-24. PMID: 10096765
- Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain. | Mills, CD., et al. 2002. J Neurotrauma. 19: 23-42. PMID: 11852976
- Corticostriatal LTP requires combined mGluR1 and mGluR5 activation. | Gubellini, P., et al. 2003. Neuropharmacology. 44: 8-16. PMID: 12559117
- Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity. | Nagaraja, RY., et al. 2005. Neuropharmacology. 49 Suppl 1: 179-87. PMID: 16009386
- Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning. | Simonyi, A., et al. 2007. Neurobiol Learn Mem. 88: 305-11. PMID: 17548216
- Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices. | Salah, A. and Perkins, KL. 2008. Neuropharmacology. 55: 47-54. PMID: 18538357
- Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings. | Musante, V., et al. 2008. Neuropharmacology. 55: 474-82. PMID: 18625255
- An interaction of oxytocin receptors with metabotropic glutamate receptors in hypothalamic astrocytes. | Kuo, J., et al. 2009. J Neuroendocrinol. 21: 1001-6. PMID: 19807846
- Estradiol-induced estrogen receptor-alpha trafficking. | Bondar, G., et al. 2009. J Neurosci. 29: 15323-30. PMID: 19955385
- Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. | Kuo, J., et al. 2010. J Neurosci. 30: 12950-7. PMID: 20881113
- Persistent receptor activity underlies group I mGluR-mediated cellular plasticity in CA3 neuron. | Young, SR., et al. 2013. J Neurosci. 33: 2526-40. PMID: 23392681
- Effects of antagonists of glutamate receptors on pro-inflammatory cytokines in the brain cortex of rats subjected to experimental autoimmune encephalomyelitis. | Sulkowski, G., et al. 2013. J Neuroimmunol. 261: 67-76. PMID: 23746391
- Metabotropic and ionotropic glutamate receptors mediate the modulation of acetylcholine release at the frog neuromuscular junction. | Tsentsevitsky, A., et al. 2017. J Neurosci Res. 95: 1391-1401. PMID: 27770577
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 367385, 10 mg | sc-361246 | 10 mg | $189.00 | |||
LY 367385, 50 mg | sc-361246A | 50 mg | $737.00 |