Molecular structure of LY 354740, CAS Number: 176199-48-7
LY 354740 (CAS 176199-48-7)
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Alternate Names:
Eglumetad; Eglumegad
Application:
LY 354740 is a highly selective and potent agonist of group II mGluR
CAS Number:
176199-48-7
Purity:
≥98%
Molecular Weight:
185.18
Molecular Formula:
C8H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 354740 is a highly selective and potent mGluR-2/3 (group II mGlu receptor) agonist. LY 354740 may act to be a conformationally constrained analog of glutamate with the ability to decrease forskolin-stimulated cAMP formation by more than 90%. Recent studies have found that activation of presynaptic metabotropic mGluR-2/3 induces long lasting inhibition of P/Q-type Ca2+ channels and the cAMP/protein kinase A pathway.
LY 354740 (CAS 176199-48-7) References
- Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. | Kłodzińska, A., et al. 1999. Neuropharmacology. 38: 1831-9. PMID: 10608278
- DmGluRA, a Drosophila metabotropic glutamate receptor, activates G-protein inwardly rectifying potassium channels in Xenopus oocytes. | Raymond, V., et al. 1999. Neurosci Lett. 269: 1-4. PMID: 10821630
- The role of glutamate receptors in antipsychotic drug action. | Ossowska, K., et al. 2000. Amino Acids. 19: 87-94. PMID: 11026477
- Glutamate receptor ligands as anxiolytics. | Chojnacka-Wójcik, E., et al. 2001. Curr Opin Investig Drugs. 2: 1112-9. PMID: 11892923
- Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment. | Harich, S., et al. 2007. Psychopharmacology (Berl). 192: 511-9. PMID: 17318501
- Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268. | Zysk, JR., et al. 2011. Synapse. 65: 64-8. PMID: 20506301
- Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY-354,740 in rat and marmoset plasma. | Gaudette, F., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1061-1062: 392-398. PMID: 28802219
- Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism. | Frouni, I., et al. 2019. Neuropharmacology. 158: 107725. PMID: 31351976
- Combined 5-HT2A and mGlu2 modulation for the treatment of dyskinesia and psychosis in Parkinson's disease. | Kwan, C., et al. 2021. Neuropharmacology. 186: 108465. PMID: 33485945
- Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset. | Nuara, SG., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 2381-2388. PMID: 34550406
- LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. | Schoepp, DD., et al. 1997. Neuropharmacology. 36: 1-11. PMID: 9144636
- Involvement of a cyclic-AMP pathway in group I metabotropic glutamate receptor responses in neonatal rat cortex. | Schaffhauser, H., et al. 1997. Eur J Pharmacol. 334: 289-97. PMID: 9369360
- Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. | Helton, DR., et al. 1998. J Pharmacol Exp Ther. 284: 651-60. PMID: 9454811
Activator of:
G α o, mGluR-2, mGluR-3, mGluR-6, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 354740, 10 mg | sc-204064 | 10 mg | $266.00 | |||
LY 354740, 50 mg | sc-204064A | 50 mg | $886.00 |