Molecular structure of LY 294002, 4′-NH2, CAS Number: 942289-87-4
LY 294002, 4′-NH2 (CAS 942289-87-4)
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Alternate Names:
PI 828
Application:
LY 294002, 4′-NH2 is a PI 3-kinase inhibitor
CAS Number:
942289-87-4
Purity:
>98%
Molecular Weight:
322.36
Molecular Formula:
C19H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY 294002, 4′-NH2 is a cell permeable 4prime-amino derivative which inhibits the p110alpha, p110beta, p110delta, and p110gamma subunits of PI 3-kinase. LY 294002, 4′-NH2 functions by preventing the phosphorylation of Akt1 in the PI 3-kinase/Akt1/mTOR pathway. In addition, the 4prime end of LY 294002, 4′-NH2 can be immobilized on an epoxy containing solid surface, which is beneficial for binding studies. Moreover, studies suggest that LY 294002, 4′-NH2 interacts with non-PI 3-kinase cellular proteins such as mTOR, ALDH1, Brd4, GSK3beta and CKIIalpha. Another useful characteristic of LY 294002, 4′-NH2 is that it functions as a reversible inhibitor of PI 3-kinase.
LY 294002, 4′-NH2 (CAS 942289-87-4) References
- Inhibition of nucleoside transport by protein kinase inhibitors. | Huang, M., et al. 2003. J Pharmacol Exp Ther. 304: 753-60. PMID: 12538831
- Exploring the specificity of the PI3K family inhibitor LY294002. | Gharbi, SI., et al. 2007. Biochem J. 404: 15-21. PMID: 17302559
- Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes. | Saleh, SN., et al. 2009. J Physiol. 587: 5361-75. PMID: 19770190
- Inhibition of contractile activity during postconditioning enhances cardioprotection by restoring sarcolemmal dystrophin through phosphatidylinositol 3-kinase. | Moriguchi, A., et al. 2010. Circ J. 74: 2393-402. PMID: 20877127
- Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis. | Hoffman, MS., et al. 2012. J Appl Physiol (1985). 113: 1184-93. PMID: 22961271
- Sequential application of a cytotoxic nanoparticle and a PI3K inhibitor enhances antitumor efficacy. | Pandey, A., et al. 2014. Cancer Res. 74: 675-685. PMID: 24121494
- Biphasic modulation of paracellular claudin-5 expression in mouse brain endothelial cells is mediated through the phosphoinositide-3-kinase/AKT pathway. | Camire, RB., et al. 2014. J Pharmacol Exp Ther. 351: 654-62. PMID: 25281324
- Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. | Rogers, SW. and Gahring, LC. 2015. PLoS One. 10: e0143319. PMID: 26619345
- Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats. | Nichols, NL., et al. 2017. J Neurosci. 37: 5834-5845. PMID: 28500219
- Spinal BDNF-induced phrenic motor facilitation requires PKCθ activity. | Agosto-Marlin, IM. and Mitchell, GS. 2017. J Neurophysiol. 118: 2755-2762. PMID: 28855298
- Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling. | Ho, MX., et al. 2018. Front Pharmacol. 9: 474. PMID: 29867480
- Differential mechanisms are required for phrenic long-term facilitation over the course of motor neuron loss following CTB-SAP intrapleural injections. | Borkowski, LF. and Nichols, NL. 2020. Exp Neurol. 334: 113460. PMID: 32916172
- Mechanisms of severe acute intermittent hypoxia-induced phrenic long-term facilitation. | Nichols, NL. and Mitchell, GS. 2021. J Neurophysiol. 125: 1146-1156. PMID: 33566744
- BDNF-induced phrenic motor facilitation shifts from PKCθ to ERK dependence with mild systemic inflammation. | Agosto-Marlin, IM., et al. 2023. J Neurophysiol. 129: 455-464. PMID: 36695529
Inhibitor of:
PI 3-kinase p110 alpha, PI 3-kinase p110 beta, PI 3-kinase p110 delta, and PI 3-kinase p110 gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 294002, 4′-NH2, 5 mg | sc-203121 | 5 mg | $357.00 | |||
LY 294002, 4′-NH2, 50 mg | sc-203121A | 50 mg | $2040.00 |