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LY-294,002 hydrochloride is a highly selective inhibitor of PI 3-kinase (IC50 values are 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively). LY-294,002 hydrochloride induces apoptosis in many cell types by blocking the PI 3-kinase/Akt anti-apoptotic pathway. LY-294,002 hydrochloride is an inhibitor of Pim-1.
1. Vlahos, C.J., et al., A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241, (1994) 2. Brunn, G.J., et al., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15, 5256-5267, (1996) 3. Vlahos, C.J., et al., Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154, 2413-2422, (1995) 4. Chasserot-Golaz et al (1998) Possible involvement of phosphatidyl-3-kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY 294002. J.Neurochem. 70 2347. 5. Ferrandi et al (2007) Phosphoinositide 3-kinase g inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J.Pharmacol. Exp.Ther. 322 923.
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