Molecular structure of LY-294,002 hydrochloride, CAS Number: 934389-88-5
LY-294,002 hydrochloride (CAS 934389-88-5)
See product citations (3)
Alternate Names:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Application:
LY-294,002 hydrochloride is a highly selective inhibitor of PI 3-kinase
CAS Number:
934389-88-5
Molecular Weight:
343.81
Molecular Formula:
C19H17NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY-294,002 hydrochloride is a highly selective inhibitor of PI 3-kinase (IC50 values are 0.31, 0.73, 1.06 and 6.60 muM for PI3Kbeta, PI3Kalpha, PI3Kdelta and PI3Kgamma respectively). LY-294,002 hydrochloride induces apoptosis in many cell types by blocking the PI 3-kinase/Akt anti-apoptotic pathway. LY-294,002 hydrochloride is an inhibitor of Pim-1.
LY-294,002 hydrochloride (CAS 934389-88-5) References
- Acidosis-induced protein tyrosine phosphorylation depends on Ca2+ influx via voltage-dependent Ca2+ channels in SHR aorta. | Rohra, DK., et al. 2004. Eur J Pharmacol. 504: 105-11. PMID: 15507226
- HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes. | López-Herrera, A., et al. 2005. Biochim Biophys Acta. 1741: 55-64. PMID: 15955449
- Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts. | Riley, JK., et al. 2006. J Biol Chem. 281: 6010-9. PMID: 16272157
- Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction. | Veggetti, M., et al. 2008. Neuroscience. 154: 1324-36. PMID: 18534762
- Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity. | Steinberg, GR., et al. 2009. Diabetes. 58: 829-39. PMID: 19136654
- Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway. | Jiménez, R., et al. 2010. J Pharmacol Exp Ther. 332: 554-61. PMID: 19906781
- 3,5,3'-triiodothyronine (T3) stimulates cell proliferation through the activation of the PI3K/Akt pathway and reactive oxygen species (ROS) production in chick embryo hepatocytes. | Gnocchi, D., et al. 2012. Steroids. 77: 589-95. PMID: 22366194
- Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells. | Del Viscovo, A., et al. 2012. Am J Physiol Endocrinol Metab. 302: E1419-30. PMID: 22414808
- Effect of Fructus Ligustri Lucidi on osteoblastic like cell-line MC3T3-E1. | Li, Q., et al. 2015. J Ethnopharmacol. 170: 88-95. PMID: 25978950
- PI3K/Akt Pathway: A Role in δ-Opioid Receptor-Mediated RGC Neuroprotection. | Husain, S., et al. 2017. Invest Ophthalmol Vis Sci. 58: 6489-6499. PMID: 29288267
- Thyroid hormones act as mitogenic and pro survival factors in rat ovarian follicles. | Canipari, R., et al. 2019. J Endocrinol Invest. 42: 271-282. PMID: 29934772
- Bapx1 upregulation is associated with ectopic mandibular cartilage development in amphibians. | Lukas, P. and Olsson, L. 2018. Zoological Lett. 4: 16. PMID: 29942645
- Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy. | Adamek, P., et al. 2019. Neuropharmacology. 146: 163-174. PMID: 30471295
- Electroacupuncture confers beneficial effects through ionotropic glutamate receptors involving phosphatidylinositol-3 kinase/Akt signaling pathway in focal cerebral ischemia in rats | Yu Ri Kim a, Ha Neui Kim a, Ji Yeon Jang a, Cheol Park b, Yung Hyun Choi b, Hwa Kyoung Shin a, Byung Tae Choi. 2012. European Journal of Integrative Medicine. 4: e413-e420.
Inhibitor of:
PI 3-kinase p110 alpha, PI 3-kinase p110 beta, PI 3-kinase p110 delta, and Pim-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY-294,002 hydrochloride, 1 mg | sc-215273 | 1 mg | $77.00 | |||
LY-294,002 hydrochloride, 5 mg | sc-215273A | 5 mg | $179.00 |