Molecular structure of LY-255283, CAS Number: 117690-79-6
LY-255283 (CAS 117690-79-6)
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Alternate Names:
1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Application:
LY-255283 is a selective, competitive BLT2 receptor antagonist
CAS Number:
117690-79-6
Purity:
98%
Molecular Weight:
360.5
Molecular Formula:
C19H28N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY-255283 is a hydroxyacetophenone that acts as a leukotriene B4 receptor antagonist. Specifically, LY-255283 competes with LTB4 (sc-201043) and [3H]LTB4 to bind to the P2Y7 (BLT1) and LTB4R2 (BLT2) receptor on lung cell membranes. Studies show that the binding coefficient of LY-255283 is smaller than LTB4, resulting in a weaker bond between the receptor and the antagonist. In addition, LY-255283 competitively reduces the contractile responses of lung parenchyma that are caused by the binding of LTB4 to the receptor. LY-255283 is an inhibitor of LTB4R2.
LY-255283 (CAS 117690-79-6) References
- Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats. | Souza, DG., et al. 2000. Eur J Pharmacol. 403: 121-8. PMID: 10969152
- Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. | Yokomizo, T., et al. 2001. J Biol Chem. 276: 12454-9. PMID: 11278893
- Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. | Herron, DK., et al. 1992. J Med Chem. 35: 1818-28. PMID: 1316967
- Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. | Silbaugh, SA., et al. 1992. Eur J Pharmacol. 223: 57-64. PMID: 1335877
- Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. | Trandafir, CC., et al. 2005. Clin Exp Pharmacol Physiol. 32: 1027-33. PMID: 16445567
- Protective actions of a leukotriene B4 antagonist in splanchnic ischemia and reperfusion in rats. | Karasawa, A., et al. 1991. Am J Physiol. 261: G191-8. PMID: 1651656
- Contribution of leukotriene B4 to airway inflammation and the effect of antagonists. | Richards, IM., et al. 1991. Ann N Y Acad Sci. 629: 274-87. PMID: 1659282
- Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. | Qiu, H., et al. 2006. Proc Natl Acad Sci U S A. 103: 6913-8. PMID: 16624877
- Biological activity of leukotriene B4 analogs: inhibition of guinea pig eosinophil migration in vitro by the 2,6-disubstituted pyridine analogs U-75,302 and U-75,485. | Taylor, BM., et al. 1991. Prostaglandins. 42: 211-24. PMID: 1664113
- Inhibitory effect of LY 255283 on the synthesis of leukotriene B(4) and thromboxane A(2) in human peripheral blood polymorphonuclear leukocytes and monocytes. | Uğur, M. and Melli, M. 1993. Mediators Inflamm. 2: 407-9. PMID: 18475555
- Relationship between calcium release and NADPH oxidase inhibition in human neutrophils. | Salmon, MD. and Ahluwalia, J. 2009. Biochem Biophys Res Commun. 384: 87-92. PMID: 19393624
- 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. | Wijkander, J., et al. 1995. J Biol Chem. 270: 26543-9. PMID: 7592874
- 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. | O'Flaherty, JT., et al. 1996. J Biol Chem. 271: 17821-8. PMID: 8663432
Inhibitor of:
LTB4R2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY-255283, 1 mg | sc-201346 | 1 mg | $100.00 | |||
LY-255283, 5 mg | sc-201346A | 5 mg | $178.00 | |||
LY-255283, 50 mg | sc-201346B | 50 mg | $650.00 |