Molecular structure of LY 2365109 hydrochloride, CAS Number: 868265-28-5
LY 2365109 hydrochloride (CAS 868265-28-5)
Alternate Names:
N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride
Application:
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor
CAS Number:
868265-28-5
Molecular Weight:
421.91
Molecular Formula:
C22H27NO5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Potent and selective glycine transporter 1 (GlyT1) inhibitor (IC50 values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Profound locomotor and respiratory impairments at higher doses.
LY 2365109 hydrochloride (CAS 868265-28-5) References
- Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. | Perry, KW., et al. 2008. Neuropharmacology. 55: 743-54. PMID: 18602930
- A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min. | Voehringer, P., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 939: 92-7. PMID: 24121745
- Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria. | Halloy, F., et al. 2021. Cell Chem Biol. 28: 1221-1234.e6. PMID: 33756123
Inhibitor of:
GlyT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY 2365109 hydrochloride, 10 mg | sc-204063 | 10 mg | $214.00 | |||
| US: Only available in the US | ||||||
LY 2365109 hydrochloride, 50 mg | sc-204063A | 50 mg | $825.00 | |||
| US: Only available in the US | ||||||