LXR beta/NER/NR1H2 (h2): 293T Lysate: sc-116107

LXRβ (h2): 293T Lysate, derived from the HEK 293T cell line, is extensively used to investigate the role of Liver X Receptor Beta (LXRβ) in human cells, focusing specifically on its function in regulating lipid metabolism and gene expression. The 293T cells, enhanced to express the SV40 large T antigen, provide an optimal environment for high-level expression of recombinant proteins, making them ideal for studies involving nuclear receptors like LXRβ. This lysate facilitates research into how LXRβ interacts with specific DNA response elements to regulate the transcription of genes involved in cholesterol, fatty acid, and glucose metabolism. Scientists employ techniques such as chromatin immunoprecipitation (ChIP), luciferase reporter assays, and electrophoretic mobility shift assays (EMSAs) to explore the binding efficiency and transcriptional activity of LXRβ on its target genes. This research helps explain the molecular mechanisms by which LXRβ influences cellular lipid homeostasis and energy balance, providing insights into fundamental biological processes related to cellular metabolism. Such studies are strictly confined to basic scientific inquiry, aiming to deepen the understanding of nuclear receptor function.