Molecular structure of Luzindole, CAS Number: 117946-91-5
Luzindole (CAS 117946-91-5)
See product citations (33)
Alternate Names:
N-Acetyl-2-benzyltryptamine; N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide
Application:
Luzindole is a selective antagonist of MEL-1B-R (melatonin receptor)
CAS Number:
117946-91-5
Purity:
≥96%
Molecular Weight:
292.37
Molecular Formula:
C19H20N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Luzindole is a synthetic compound structured as an indole derivative. In the realm of research, it is used as a tool compound to understand the function of specific receptors, not as a therapeutic agent but as a means to dissect receptor-mediated signaling pathways. In biochemical assays to characterize the binding affinity and selectivity of receptor-ligand interactions. Luzindole is also applied in the investigation of cellular communication processes, helping to elucidate the role of receptors in various cellular responses. It is also often employed as a reference compound in the development of detection and quantification methods for similar indole-based structures.
Luzindole (CAS 117946-91-5) References
- Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. | Browning, C., et al. 2000. Br J Pharmacol. 129: 877-86. PMID: 10696085
- Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats. | Yu, CX., et al. 2000. Neurosci Lett. 282: 161-4. PMID: 10717416
- Luzindole, a melatonin receptor antagonist, inhibits the transient outward K+ current in rat cerebellar granule cells. | Zhou, MO., et al. 2003. Brain Res. 970: 169-77. PMID: 12706258
- Pharmacology and function of melatonin receptors. | Dubocovich, ML. 1988. FASEB J. 2: 2765-73. PMID: 2842214
- Luzindole (N-0774): a novel melatonin receptor antagonist. | Dubocovich, ML. 1988. J Pharmacol Exp Ther. 246: 902-10. PMID: 2843633
- The melatonin receptor antagonist luzindole induces Ca2+ mobilization, reactive oxygen species generation and impairs trypsin secretion in mouse pancreatic acinar cells. | Estaras, M., et al. 2019. Biochim Biophys Acta Gen Subj. 1863: 129407. PMID: 31381958
- Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice. | Luo, Y., et al. 2020. Innate Immun. 26: 319-327. PMID: 31779498
- The melatonin receptor antagonist luzindole induces the activation of cellular stress responses and decreases viability of rat pancreatic stellate cells. | Estaras, M., et al. 2020. J Appl Toxicol. 40: 1554-1565. PMID: 32567733
- Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway. | Ma, WY., et al. 2021. Acta Pharmacol Sin. 42: 921-931. PMID: 32839503
- Luzindole and 4P-PDOT block the effect of melatonin on bovine granulosa cell apoptosis and cell cycle depending on its concentration. | Wang, S., et al. 2021. PeerJ. 9: e10627. PMID: 33732541
- Acute blockade of endogenous melatonin by Luzindole, with or without peripheral LPS injection, induces jejunal inflammation and morphological alterations in Swiss mice. | Matos, RS., et al. 2021. Braz J Med Biol Res. 54: e11215. PMID: 34431873
- Melatonin receptors: are there multiple subtypes? | Dubocovich, ML. 1995. Trends Pharmacol Sci. 16: 50-6. PMID: 7762083
- Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. | Constantinescu, CS., et al. 1997. Pathobiology. 65: 190-4. PMID: 9396042
- Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. | Dubocovich, ML., et al. 1998. FASEB J. 12: 1211-20. PMID: 9737724
- The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat. | Sugawara, T., et al. 1998. Invest Ophthalmol Vis Sci. 39: 2458-65. PMID: 9804154
Inhibitor of:
ASMT, MEL-1A-R, and MEL-1B-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Luzindole, 5 mg | sc-202700 | 5 mg | $104.00 | |||
Luzindole, 25 mg | sc-202700A | 25 mg | $283.00 | |||
Luzindole, 100 mg | sc-202700B | 100 mg | $567.00 | |||
Luzindole, 250 mg | sc-202700C | 250 mg | $861.00 | |||
Luzindole, 2.5 g | sc-202700D | 2.5 g | $4692.00 |