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Luteoreticulin (CAS 22388-89-2)

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Alternate Names:
Griseulin
Application:
Luteoreticulin is a nitrophenyl pyranone with immunosuppresive effects
CAS Number:
22388-89-2
Purity:
>99%
Molecular Weight:
341.4
Molecular Formula:
C19H19NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Luteoreticulin (LTR) is a glycoprotein present in the extracellular matrix of various mammalian cells. Its significance lies in its involvement in essential cellular processes like adhesion, migration, proliferation, and differentiation. Over the last decade, extensive research has shed light on Luteoreticulin′s multifaceted impacts on both biochemical and physiological aspects. Scientific researchers have employed Luteoreticulin in diverse applications, leveraging its influence on cell adhesion, migration, proliferation, and differentiation. Scientists have utilized it as a tool to investigate the intricate structure and function of the extracellular matrix, delving into its role in cell signaling. Luteoreticulin interacts with cell surface receptors triggering intracellular signaling pathways, culminating in substantial alterations in cellular behavior.


Luteoreticulin (CAS 22388-89-2) References

  1. Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line.  |  Sugimoto, Y., et al. 2014. Angew Chem Int Ed Engl. 53: 1560-4. PMID: 24402879
  2. Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology.  |  Hertweck, C. 2015. Trends Biochem Sci. 40: 189-99. PMID: 25757401
  3. Reinvigorating natural product combinatorial biosynthesis with synthetic biology.  |  Kim, E., et al. 2015. Nat Chem Biol. 11: 649-59. PMID: 26284672
  4. Harnessing natural product assembly lines: structure, promiscuity, and engineering.  |  Ladner, CC. and Williams, GJ. 2016. J Ind Microbiol Biotechnol. 43: 371-87. PMID: 26527577
  5. Generation of superoxide anion and hydrogen peroxide during redox cycling of 5-(4-nitrophenyl)-penta-2,4-dienal by mammalian microsomes and enzymes.  |  Docampo, R., et al. 1988. Chem Biol Interact. 65: 123-31. PMID: 2835186
  6. Supercritical Fluid Extraction Enhances Discovery of Secondary Metabolites from Myxobacteria.  |  Bader, CD., et al. 2020. Anal Chem. 92: 15403-15411. PMID: 33171050
  7. The structure of luteoreticulin, a nitro-containing metabolite of Streptomyces luteoreticuli.  |  Koyama, Y., et al. 1969. Tetrahedron Lett. 355-8. PMID: 5779746
  8. High-performance liquid chromatography comparison of supercritical-fluid extraction and solvent extraction of microbial fermentation products.  |  Cocks, S., et al. 1995. J Chromatogr A. 697: 115-22. PMID: 7780576

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Luteoreticulin, 500 µg

sc-202213
500 µg
$357.00