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Lumiflavine (CAS 1088-56-8)

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Alternate Names:
7,8,10-trimethylbenzo[g]pteridine-2,4-dione
Application:
Lumiflavine is a riboflavin uptake inhibitor used to study riboflavin uptake in intestinal epithelial (Caco-2) and other epithelial cells
CAS Number:
1088-56-8
Purity:
≥95%
Molecular Weight:
256.26
Molecular Formula:
C13H12N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lumiflavine (Lumiflavin) is produced by the photolysis of vitamin B2 (Riboflavin). Lumiflavine, a riboflavin uptake inhibitor, is used to study riboflavin uptake in intestinal epithelial (Caco-2) and other epithelial cells. It acts as a fluorescent label for proteins and nucleic acids in biochemical assays and in microscopy.


Lumiflavine (CAS 1088-56-8) References

  1. Photophysical properties of lumichromes in water.  |  Sikorski, M., et al. 2001. J Photochem Photobiol B. 60: 114-9. PMID: 11470567
  2. Mechanism of riboflavin uptake by cultured human retinal pigment epithelial ARPE-19 cells: possible regulation by an intracellular Ca2+-calmodulin-mediated pathway.  |  Said, HM., et al. 2005. J Physiol. 566: 369-77. PMID: 15878949
  3. Enzymatic catalysis: the emerging role of conceptual density functional theory.  |  Roos, G., et al. 2009. J Phys Chem B. 113: 13465-75. PMID: 19754087
  4. Multicomponent spectrophotometric assay of riboflavine and photoproducts.  |  Ahmad, I. and Rapson, HD. 1990. J Pharm Biomed Anal. 8: 217-23. PMID: 2094420
  5. Redox cofactor from biological energy transduction as molecularly tunable energy-storage compound.  |  Lee, M., et al. 2013. Angew Chem Int Ed Engl. 52: 8322-8. PMID: 23784869
  6. Intermolecular complexes between N-methyl-1,4-dihydronicotinamide and flavines. The influence of steric and electronic factors on complex formation and the rate of flavine-dependent dihydronicotinamide dehydrogenation.  |  Blankenhorn, G. 1975. Biochemistry. 14: 3172-6. PMID: 238584
  7. Organic nanohybrids for fast and sustainable energy storage.  |  Lee, M., et al. 2014. Adv Mater. 26: 2558-65. PMID: 24488928
  8. Transcriptomic response of Anopheles gambiae sensu stricto mosquito larvae to Curry tree (Murraya koenigii) phytochemicals.  |  Mang'era, CM., et al. 2021. Parasit Vectors. 14: 1. PMID: 33388087
  9. Variations in riboflavin binding by human plasma: identification of immunoglobulins as the major proteins responsible.  |  Innis, WS., et al. 1985. Biochem Med. 34: 151-65. PMID: 4084240
  10. Flavine-protein interactions in flavoenzymes. Temperature-jump and stopped-flow studies of flavine analog binding to the apoprotein of Azotobacter flavodoxin.  |  Barman, BG. and Tollin, G. 1972. Biochemistry. 11: 4746-54. PMID: 4655252
  11. Quenching of fluorescence by oxygen. A probe for structural fluctuations in macromolecules.  |  Lakowicz, JR. and Weber, G. 1973. Biochemistry. 12: 4161-70. PMID: 4795686
  12. Metabolites of riboflavine in milk, urine and tissues of animals in relation to alimentary symbiotic bacteria.  |  Owen, EC. and West, DW. 1970. Br J Nutr. 24: 45-60. PMID: 5424273
  13. The primary cytotoxicity in ultraviolet-a-irradiated riboflavin solution is derived from hydrogen peroxide.  |  Sato, K., et al. 1995. J Invest Dermatol. 105: 608-12. PMID: 7561167
  14. Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas.  |  Moe, AJ., et al. 1994. Placenta. 15: 137-46. PMID: 8008729
  15. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells.  |  Said, HM. and Ma, TY. 1994. Am J Physiol. 266: G15-21. PMID: 8304455

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lumiflavine, 25 mg

sc-224045
25 mg
$387.00

Lumiflavine, 100 mg

sc-224045A
100 mg
$733.00

What is the solubility of this product?

Asked by: hawkeye11
This chemical, Lumiflavine (CAS 1088-56-8), is soluble in TFA (4 mg/0.8mL).
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Various publications cite the use of LumiflavineVarious publications cite the use of Lumiflavine, a riboflavin uptake inhibitor, to study the riboflavin uptake in intestinal epithelial (Caco-2) and other epithelial cells. -SCBT Publication Review
Date published: 2015-02-05
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Lumiflavine is rated 5.0 out of 5 by 1.
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