Molecular structure of Lubiprostone, CAS Number: 136790-76-6
Lubiprostone (CAS 136790-76-6)
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Application:
Lubiprostone is a prostaglandin E1 metabolite
CAS Number:
136790-76-6
Purity:
≥98%
Molecular Weight:
390.46
Molecular Formula:
C20H32F2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, and increase gastrointestinal transit.
Lubiprostone (CAS 136790-76-6) References
- Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. | MacDonald, KD., et al. 2008. Am J Physiol Lung Cell Mol Physiol. 295: L933-40. PMID: 18805957
- Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. | Fei, G., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 296: G823-32. PMID: 19179625
- Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. | Joo, NS., et al. 2009. Am J Physiol Lung Cell Mol Physiol. 296: L811-24. PMID: 19233902
- Lubiprostone stimulates duodenal bicarbonate secretion in rats. | Mizumori, M., et al. 2009. Dig Dis Sci. 54: 2063-9. PMID: 19657734
- Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. | Fei, G., et al. 2010. J Pharmacol Exp Ther. 334: 333-40. PMID: 20406855
- Lubiprostone targets prostanoid EP₄ receptors in ovine airways. | Cuthbert, AW. 2011. Br J Pharmacol. 162: 508-20. PMID: 20883477
- Lubiprostone activates Cl- secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84. | Ao, M., et al. 2011. Dig Dis Sci. 56: 339-51. PMID: 21140215
- Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota. | Musch, MW., et al. 2013. Dig Dis Sci. 58: 668-77. PMID: 23329012
- Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP1)-mediated Pathway. | Chan, WW. and Mashimo, H. 2013. J Neurogastroenterol Motil. 19: 312-8. PMID: 23875097
- Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus. | Krüger, L., et al. 2020. Am J Physiol Gastrointest Liver Physiol. 318: G613-G623. PMID: 32068440
- Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis. | Enomoto, M., et al. 2022. Dig Liver Dis. 54: 1392-1402. PMID: 35514019
- Lubiprostone is non-selective activator of cAMP-gated ion channels and Clc-2 has a minor role in its prosecretory effect in intestinal epithelial cells. | Oak, AA., et al. 2022. Mol Pharmacol. 102: 106-15. PMID: 35680165
- Lubiprostone significantly represses fatty liver diseases via induction of mucin and HDL release in mice. | Kim, MY., et al. 2022. Life Sci. 311: 121176. PMID: 36372211
Activator of:
CLC-2, and GC-C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lubiprostone, 1 mg | sc-211755 | 1 mg | $262.00 |