LTD4 (Leukotriene D4) (CAS 73836-78-9)
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LTD4 (Leukotriene D4) is a bioactive eicosanoid that plays a central role in the inflammatory response, particularly in the pathophysiology of asthma and allergic reactions. It is a product of the 5-lipoxygenase pathway and acts by binding to cysteinyl leukotriene receptors on target cells. In research, LTD4 (Leukotriene D4) is utilized to study the signaling pathways involved in bronchoconstriction, increased vascular permeability, and eosinophil recruitment. By examining the effects of LTD4 (Leukotriene D4) on various cell types, researchers can elucidate the cellular mechanisms that contribute to inflammation and hypersensitivity reactions. Additionally, LTD4 (Leukotriene D4) serves as a tool to test the efficacy of leukotriene receptor antagonists and to investigate targets for intervention in conditions associated with leukotriene-mediated inflammation.
LTD4 (Leukotriene D4) (CAS 73836-78-9) References
- Cysteinyl leukotriene receptors. | Evans, JF. 2002. Prostaglandins Other Lipid Mediat. 68-69: 587-97. PMID: 12432945
- Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts. | Tokuriki, S., et al. 2007. Clin Immunol. 125: 88-94. PMID: 17627891
- Cysteinyl leukotrienes enhance growth of human airway epithelial cells. | Leikauf, GD., et al. 1990. Am J Physiol. 259: L255-61. PMID: 2171354
- Leukotriene C4 stimulates angiogenesis in bovine carotid artery endothelial cells in vitro. | Kanayasu, T., et al. 1989. Biochem Biophys Res Commun. 159: 572-8. PMID: 2467671
- Effects of leukotriene D4 and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients. | Zhu, Z., et al. 2018. Clin Respir J. 12: 587-594. PMID: 27696764
- New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses. | Chiang, N., et al. 2018. FASEB J. 32: 4043-4052. PMID: 29490167
- Metabolism of leukotrienes. | Hammarström, S., et al. 1985. Mol Cell Biochem. 69: 7-16. PMID: 3001504
- Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives. | Al-Azzam, N. and Elsalem, L. 2020. Life Sci. 260: 118452. PMID: 32956660
- Cysteinyl leukotriene D4 (LTD4) promotes airway epithelial cell inflammation and remodelling. | Dholia, N., et al. 2021. Inflamm Res. 70: 109-126. PMID: 33136175
- Leukotriene D4 paradoxically limits LTC4-driven platelet activation and lung immunopathology. | Liu, T., et al. 2021. J Allergy Clin Immunol. 148: 195-208.e5. PMID: 33285161
- Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. | Dahlén, SE., et al. 1981. Proc Natl Acad Sci U S A. 78: 3887-91. PMID: 6267608
- Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. | Dahlén, SE., et al. 1983. Proc Natl Acad Sci U S A. 80: 1712-6. PMID: 6300870
- The actions of leukotrienes C4 and D4 on guinea-pig isolated hearts. | Letts, LG. and Piper, PJ. 1982. Br J Pharmacol. 76: 169-76. PMID: 6896291
- Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. | Drazen, JM., et al. 1980. Proc Natl Acad Sci U S A. 77: 4354-8. PMID: 6933488
- Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro. | Marom, Z., et al. 1982. Am Rev Respir Dis. 126: 449-51. PMID: 7125334
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTD4 (Leukotriene D4), 50 µg | sc-201048 | 50 µg | $362.00 |