LTC4 (Leukotriene C4), and other leukotrienes, are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis; primarily acting through specific G protein-coupled receptors. This product is a potent arachidonic acid (sc-200770)-derived agonist for contraction of smooth muscle and has been shown to induce microvascular permeability and mucus secretion in airways. Furthermore, this product has been shown to enhance growth of human airway epithelial cells, reduce myocardial contractility and coronary blood flow, induce long lasting hypotension, and stimulate angiogenesis. LTC4 (Leukotriene C4) is an inhibitor of MGST.
1. Leikauf, G D., et al., 1990. Cysteinyl leukotrienes enhance growth of human airway epithelial cells. The American journal of physiology. 259(4 Pt 1): L255-61. PMID: 2171354
2. Kanayasu, T., et al., 1989. Leukotriene C4 stimulates angiogenesis in bovine carotid artery endothelial cells in vitro. Biochemical and biophysical research communications. 159(2): 572-8. PMID: 2467671
3. Hulting, A L., et al., 1985. Leukotriene C4 as a mediator of luteinizing hormone release from rat anterior pituitary cells. Proceedings of the National Academy of Sciences of the United States of America. 82(11): 3834-8. PMID: 2987949
4. Dahlén, S E., et al., 1981. Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proceedings of the National Academy of Sciences of the United States of America. 78(6): 3887-91. PMID: 6267608
5. Dahlén, S E., et al., 1983. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proceedings of the National Academy of Sciences of the United States of America. 80(6): 1712-6. PMID: 6300870
6. Letts, L G., et al., 1982. The actions of leukotrienes C4 and D4 on guinea-pig isolated hearts. British journal of pharmacology. 76(1): 169-76. PMID: 6896291
7. Marom, Z., et al., 1982. Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro. The American review of respiratory disease. 126(3): 449-51. PMID: 7125334
8. Funk, C D., et al., 2001. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science (New York, N.Y.). 294(5548): 1871-5. PMID: 11729303
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