LTA4H Antibody (D-6): sc-390567
- LTA4H Antibody (D-6) is a mouse monoclonal IgG1 κ LTA4H antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 585-611 at the C-terminus of LTA4H of human origin
- LTA4H Antibody (D-6) is recommended for detection of LTA4H of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-LTA4H Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for LTA4H Antibody (D-6) for WB applications. These reagents are now offered in bundles with LTA4H Antibody (D-6) (see ordering information below).
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LTA4H Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects LTA4H protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LTA4H Antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LTA4H, or Leukotriene A4-hydrolase, plays a crucial role in the metabolism of leukotrienes, which are bioactive lipids derived from arachidonic acid that are essential for mediating inflammatory responses and host defense mechanisms. Located primarily in the cytosol, LTA4H is a zinc-dependent enzyme that exhibits both epoxide hydrolase and aminopeptidase activities. LTA4H epoxide hydrolase function is particularly significant as LTA4H catalyzes the conversion of leukotriene A4 to leukotriene B4, a potent lipid mediator that acts as a chemoattractant, guiding immune cells to sites of inflammation and infection. LTA4H aminopeptidase activity further contributes to regulatory role in immune responses by processing peptide substrates. The human LTA4H gene encodes a protein consisting of 610 amino acids, and proper functioning is vital for maintaining immune homeostasis and responding effectively to pathogenic challenges.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LTA4H Antibody (D-6) References:
- Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. | Thunnissen, MM., et al. 2001. Nat Struct Biol. 8: 131-5. PMID: 11175901
- Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375. | Rudberg, PC., et al. 2002. Proc Natl Acad Sci U S A. 99: 4215-20. PMID: 11917124
- Molecular cloning and amino acid sequence of leukotriene A4 hydrolase. | Funk, CD., et al. 1987. Proc Natl Acad Sci U S A. 84: 6677-81. PMID: 2821541
- Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary structure of an enzyme involved in eicosanoid synthesis. | Minami, M., et al. 1987. J Biol Chem. 262: 13873-6. PMID: 3654641
- High-level expression and purification of human leukotriene A4 hydrolase from insect cells infected with a baculovirus vector. | Gierse, JK., et al. 1993. Protein Expr Purif. 4: 358-66. PMID: 8251746
- Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus. | Parnas, BL., et al. 1996. J Nat Prod. 59: 962-4. PMID: 8904845
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTA4H Antibody (D-6) | sc-390567 | 200 µg/ml | $322.00 | |||
LTA4H Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-527638 | 200 µg Ab; 10 µg BP | $361.00 | |||
LTA4H Antibody (D-6): m-IgG1 BP-HRP Bundle | sc-533011 | 200 µg Ab; 20 µg BP | $361.00 | |||
LTA4H Antibody (D-6) AC | sc-390567 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LTA4H Antibody (D-6) HRP | sc-390567 HRP | 200 µg/ml | $322.00 | |||
LTA4H Antibody (D-6) FITC | sc-390567 FITC | 200 µg/ml | $336.00 | |||
LTA4H Antibody (D-6) PE | sc-390567 PE | 200 µg/ml | $349.00 | |||
LTA4H Antibody (D-6) Alexa Fluor® 488 | sc-390567 AF488 | 200 µg/ml | $364.00 | |||
LTA4H Antibody (D-6) Alexa Fluor® 546 | sc-390567 AF546 | 200 µg/ml | $364.00 | |||
LTA4H Antibody (D-6) Alexa Fluor® 594 | sc-390567 AF594 | 200 µg/ml | $364.00 | |||
LTA4H Antibody (D-6) Alexa Fluor® 647 | sc-390567 AF647 | 200 µg/ml | $364.00 | |||
LTA4H Antibody (D-6) Alexa Fluor® 680 | sc-390567 AF680 | 200 µg/ml | $364.00 | |||
LTA4H Antibody (D-6) Alexa Fluor® 790 | sc-390567 AF790 | 200 µg/ml | $364.00 | |||
LTA4H (D-6) Neutralizing Peptide | sc-390567 P | 100 µg/0.5 ml | $69.00 |