LTA4 (Leukotriene A4 methyl ester) CAS: 73466-12-3
MF: C21H32O3
MW: 332.5
An unstable intermediate in the biosynthesis of LTB4 and LTC4.

LTA4 (Leukotriene A4 methyl ester) (CAS 73466-12-3)

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Application: LTA4 (Leukotriene A4 methyl ester) is an unstable intermediate in the biosynthesis of LTB4 and LTC4
CAS Number: 73466-12-3
Purity: ≥95%
Molecular Weight: 332.5
Molecular Formula: C21H32O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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LTA4 (Leukotriene A4 methyl ester) is a member of the leukotriene family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes possess a conjugated triene structure which gives them their name. They are generally isolated from leukocytes and primarily act through specific G protein-coupled receptors. Leukotriene A4 methyl ester is an unstable intermediate in the biosynthesis of LTB4 (sc-201043) and LTC4 (sc-201046). Observations show that the naturally occuring free acid is a substrate for LTA4H (LTA4 hydrolase) and LTC4 synthase and plays a central role in transcellular leukotriene and lipoxin biosynthesis. It has also been shown to mobilize Ca2+ in human neutrophils. This product is supplied as the methyl ester for higher stability.


References

1. Samuelsson, B., et al. 1987. Science. 237: 1171-1176. PMID: 2820055
2. Samuelsson, B. and Funk, C.D. 1989. J. Biol. Chem. 264: 19469-19472. PMID: 2555321
3. Maclouf, J., et al. 1989. Pharmacol. Res. 21: 1-7. PMID: 2657701
4. Luscinskas, F.W., et al. 1990. Biochem. Pharmacol. 39: 355-365. PMID: 2154229
5. Fiore, S. and Serhan, C.N. 1990. J. Exp. Med. 172: 1451-1457. PMID: 2172436

Formulation :
A solution in hexane containing triethylamine
Physical State :
Liquid
Solubility :
Soluble in chloroform.
Storage :
Store at -80° C
Melting Point :
28-32° C (lit.)
Boiling Point :
68° C
Refractive Index :
n20D 1.55
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6478221
MDL Number :
MFCD00065847
SMILES :
CCCCC/C=C\\C/C=C\\C=C\\C=C\\[[email protected]]1[[email protected]@H](O1)CCCC(=O)OC

Download SDS (MSDS)

Certificate of Analysis

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