Molecular structure of LTA3 (Leukotriene A3 methyl ester), CAS Number: 83851-38-1
LTA3 (Leukotriene A3 methyl ester) (CAS 83851-38-1)
Application:
LTA3 (Leukotriene A3 methyl ester) is a suicide inhibitor of LTA4 hydrolase
CAS Number:
83851-38-1
Molecular Weight:
334.5
Molecular Formula:
C21H34O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LTA3 (Leukotriene A3 methyl ester) is a member of the leukotrienes which are potent, arachidonic acid-derived eicosanoid lipid mediators. Leukotrienes have demonstrated to play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes primarily act through specific G protein-coupled receptors. LTA3 (Leukotriene A3 methyl ester) is an analogue of LTA4 that lacks a C14-C15 double bond. The compound has been observed as a potent suicide inhibitor of LTA4H (LTA4 hydrolase). It has been synthesized from Mead acid (sc-200772) via 5-lipoxygenase. The compound has also been observed to be inhibit rat and human neutrophil LTA4H (LTA4 hydrolases).
LTA3 (Leukotriene A3 methyl ester) (CAS 83851-38-1) References
- Prostaglandins and leukotrienes: advances in eicosanoid biology. | Funk, CD. 2001. Science. 294: 1871-5. PMID: 11729303
- Lipoxin generation by permeabilized human platelets. | Romano, M. and Serhan, CN. 1992. Biochemistry. 31: 8269-77. PMID: 1381961
- Mechanism-based inactivation of leukotriene A4 hydrolase during leukotriene B4 formation by human erythrocytes. | Orning, L., et al. 1990. J Biol Chem. 265: 14911-6. PMID: 2168394
- Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase. | Evans, JF., et al. 1985. J Biol Chem. 260: 10966-70. PMID: 2993297
- Properties of highly purified leukotriene C4 synthase of guinea pig lung. | Yoshimoto, T., et al. 1988. J Clin Invest. 81: 866-71. PMID: 3343345
- Products derived from 5,8,11-eicosatrienoic acid by the 5-lipoxygenase-leukotriene pathway. | Jakschik, BA., et al. 1983. J Biol Chem. 258: 12797-800. PMID: 6313677
- Structural characterization of the covalent attachment of leukotriene A3 to leukotriene A4 hydrolase. | Mancini, JA., et al. 1998. Arch Biochem Biophys. 354: 117-24. PMID: 9633605
Inhibitor of:
Enzyme, and LTA4H.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTA3 (Leukotriene A3 methyl ester), 50 µg | sc-200490 | 50 µg | $167.00 | |||
LTA3 (Leukotriene A3 methyl ester), 1 mg | sc-200490A | 1 mg | $2000.00 |