LT-β Antibody (399CT9.3.4): sc-517341

LT-β Antibody (399CT9.3.4) is a mouse monoclonal IgM antibody that detects the LT-beta protein of human origin by western blotting (WB). Anti-LT-beta antibody (399CT9.3.4) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. The LT-beta protein, also known as lymphotoxin-β or TNFC, plays a crucial role in the immune system by participating in the regulation of immune and inflammatory responses. LT-beta is a type II membrane protein that shares significant homology with tumor necrosis factor (TNF) and lymphotoxin-α (LT-α), which are key players in immune signaling. LT-beta is primarily expressed on the surface of activated lymphocytes, where LT-beta forms a heterotrimeric complex with LT-α, anchoring LT-α to the cell membrane and facilitating interaction with the LT-β receptor, a TNF receptor-related protein. This interaction is vital for the development and maintenance of secondary lymphoid organs, as well as for the activation of immune responses. Notably, the gene encoding LT-beta is located in the major histocompatibility complex region on human chromosome 6p21.33, highlighting significance in immune regulation and potential implications in various diseases, including non-Hodgkin′s lymphomas. With proven detection of LT-beta in human samples, LT-beta monoclonal antibody (399CT9.3.4) is an essential reagent for researchers investigating the complexities of immune signaling pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LT-β Antibody (399CT9.3.4) References:

1. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.  |  Cui, CY., et al. 2006. Proc Natl Acad Sci U S A. 103: 9142-7. PMID: 16738056
2. Expression of lymphotoxin beta governs immunity at two distinct levels.  |  Junt, T., et al. 2006. Eur J Immunol. 36: 2061-75. PMID: 16841297
3. High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations.  |  O'Rourke, KP., et al. 2008. Rheumatol Int. 28: 979-86. PMID: 18379788
4. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.  |  Browning, JL., et al. 1993. Cell. 72: 847-56. PMID: 7916655
5. A lymphotoxin-beta-specific receptor.  |  Crowe, PD., et al. 1994. Science. 264: 707-10. PMID: 8171323
6. The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping.  |  Nakamura, T., et al. 1995. Genomics. 30: 312-9. PMID: 8586432
7. Genes in a 220-kb region spanning the TNF cluster in human MHC.  |  Nalabolu, SR., et al. 1996. Genomics. 31: 215-22. PMID: 8824804
8. Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas.  |  Warzocha, K., et al. 1997. Biochem Biophys Res Commun. 238: 273-6. PMID: 9299492