LSm10 Antibody (2522C1a): sc-81314
- LSm10 Antibody (2522C1a) is a mouse monoclonal IgG2a LSm10 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the N-terminus of LSm10 of human origin
- recommended for detection of LSm10 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LSm10 Antibody (2522C1a). This work is in progress.
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LSm10 Antibody (2522C1a) is a mouse monoclonal IgG2a antibody that detects LSm10 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-LSm10 antibody (2522C1a) is available as the non-conjugated format. LSm10 protein, also known as U7 snRNA-associated Sm-like protein LSm10, plays a vital role in the nucleus as a member of the small nuclear ribonucleoproteins (snRNP) Sm protein family. LSm10 protein is essential for the assembly of snRNPs, which are crucial for pre-mRNA splicing and the processing of histone RNA. Specifically, LSm10 protein interacts with the survival of motor neurons (SMN) complex, facilitating the binding of Sm proteins to the SMN protein, a critical step in snRNP assembly. Proper localization and function of LSm10 protein are paramount, as LSm10 works alongside LSm11 to ensure the effective functioning of U7 snRNP, which is involved in the splicing of animal histone pre-mRNAs. Additionally, LSm10 protein associates with pICln, a protein that modulates the assembly of Sm proteins on U RNA, highlighting LSm10′s role in regulating RNA processing pathways. LSm10 protein interactions with U7 snRNA and pICln open avenues for innovative therapeutic strategies, such as the use of modified U7 snRNA derivatives to influence specific pre-mRNA splicing events, potentially advancing the field of antisense gene therapy.
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LSm10 Antibody (2522C1a) References:
- Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. | Pillai, RS., et al. 2001. EMBO J. 20: 5470-9. PMID: 11574479
- A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. | Dominski, Z., et al. 2002. Genes Dev. 16: 58-71. PMID: 11782445
- Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. | Pillai, RS., et al. 2003. Genes Dev. 17: 2321-33. PMID: 12975319
- A protein interaction framework for human mRNA degradation. | Lehner, B. and Sanderson, CM. 2004. Genome Res. 14: 1315-23. PMID: 15231747
- The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein. | Schümperli, D. and Pillai, RS. 2004. Cell Mol Life Sci. 61: 2560-70. PMID: 15526162
- Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. | Azzouz, TN., et al. 2005. J Biol Chem. 280: 34435-40. PMID: 16087681
- Towards a proteome-scale map of the human protein-protein interaction network. | Rual, JF., et al. 2005. Nature. 437: 1173-8. PMID: 16189514
- ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. | Wagner, EJ. and Marzluff, WF. 2006. Mol Cell Biol. 26: 6702-12. PMID: 16914750
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LSm10 Antibody (2522C1a) | sc-81314 | 100 µg/ml | $339.00 |