LSAMP Antibody (Y-13A): sc-74210

LSAMP Antibody (Y-13A) is a mouse monoclonal IgG1 antibody that detects LSAMP protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-LSAMP antibody (Y-13A) is available as the non-conjugated monoclonal isotype antibody. LSAMP protein, or limbic system-associated membrane protein, is a crucial neuronal surface glycoprotein predominantly located in the cortical and subcortical regions of the limbic system, where LSAMP is expressed on the surface of neuronal somata and proximal dendrites. As a member of the immunoglobulin superfamily and part of the IgLON subfamily of cell adhesion molecules, LSAMP plays a significant role in the regulation of neurite outgrowth and the formation of neural circuits within limbic pathways, which are essential for emotional regulation and memory processing. LSAMP′s structure includes three immunoglobulin domains and a glycosylphosphatidylinositol anchor, contributing to stability and function in cell adhesion. Notably, LSAMP exhibits a high degree of conservation between rodents and humans, with a 99% sequence identity, underscoring evolutionary importance. Furthermore, emerging research suggests that LSAMP may act as a tumor suppressor in renal carcinomas, highlighting potential relevance in cancer biology.

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LSAMP Antibody (Y-13A) References:

1. Distinct domains of the limbic system-associated membrane protein (LAMP) mediate discrete effects on neurite outgrowth.  |  Eagleson, KL., et al. 2003. Mol Cell Neurosci. 24: 725-40. PMID: 14664821
2. Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene.  |  Pimenta, AF. and Levitt, P. 2004. Genomics. 83: 790-801. PMID: 15081109
3. Diglons are heterodimeric proteins composed of IgLON subunits, and Diglon-CO inhibits neurite outgrowth from cerebellar granule cells.  |  Reed, J., et al. 2004. J Cell Sci. 117: 3961-73. PMID: 15265982
4. Distribution of the limbic system-associated membrane protein (LAMP) in pigeon forebrain and midbrain.  |  Yamamoto, K. and Reiner, A. 2005. J Comp Neurol. 486: 221-42. PMID: 15844168
5. The IgLON family in epithelial ovarian cancer: expression profiles and clinicopathologic correlates.  |  Ntougkos, E., et al. 2005. Clin Cancer Res. 11: 5764-8. PMID: 16115914
6. Rats displaying distinct exploratory activity also have different expression patterns of gamma-aminobutyric acid- and cholecystokinin-related genes in brain regions.  |  Nelovkov, A., et al. 2006. Brain Res. 1100: 21-31. PMID: 16769038
7. Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours.  |  Reed, JE., et al. 2007. Neuropathol Appl Neurobiol. 33: 77-85. PMID: 17239010
8. cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP).  |  Pimenta, AF., et al. 1996. Gene. 170: 189-95. PMID: 8666243
9. AvGp50, a predominantly axonally expressed glycoprotein, is a member of the IgLON's subfamily of cell adhesion molecules (CAMs).  |  Hancox, KA., et al. 1997. Brain Res Mol Brain Res. 44: 273-85. PMID: 9073169

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LSAMP Antibody (Y-13A) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LSAMP Antibody (Y-13A) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LSAMP Antibody (Y-13A) Specifications

Alternate Product Name: LSAMP

Product Clone Name: Y-13A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: LSAMP

Epitope Species: human

Product Reactivity/Detection: LSAMP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LSAMP Antibody (Y-13A): N/A