LRRFIP1 Antibody (32): sc-135917
- LRRFIP1 Antibody (32) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 210-415 of LRRFIP1 of human origin
- recommended for detection of LRRFIP1 of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LRRFIP1 Antibody (32). This work is in progress.
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LRRFIP1 Antibody (32) is a mouse monoclonal IgG1 antibody that detects LRRFIP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). LRRFIP1, also known as GCF2, is a 738 amino acid protein that plays a crucial role as a transcriptional repressor, preferentially binding to the GC-rich consensus sequence (5′-AGCCCCCGGCG-3′). This binding may regulate the expression of key growth factors such as tumor necrosis factor (TNF), epidermal growth factor receptor (EGFR), and platelet-derived growth factor A (PDGF-A), thereby influencing various cellular processes including smooth muscle cell proliferation following arterial injury. LRRFIP1′s N-terminus exhibits high homology to the coiled-coil domain of FLAP, a protein that interacts with the leucine-rich repeat (LRR) of Flightless I, suggesting a functional link between LRRFIP1 and the actin cytoskeleton through its association with Flightless I. LRRFIP1 has a high affinity for double-stranded RNA, with two molecules binding to the TaR stem, and its RNA binding domain contains a lysine-rich motif, highlighting its potential role in RNA regulation within mammalian cells. The unique structural features and interactions of LRRFIP1 underscore its importance in cellular signaling and gene expression regulation, making anti-LRRFIP1 antibody (32) an essential tool for researchers studying these pathways.
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LRRFIP1 Antibody (32) References:
- The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. | Yang, P., et al. 2010. Nat Immunol. 11: 487-94. PMID: 20453844
- Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1. | Nguyen, JB. and Modis, Y. 2013. J Struct Biol. 181: 82-8. PMID: 23099021
- A variant in the LRRFIP1 gene is associated with adiposity and inflammation. | Plourde, M., et al. 2013. Obesity (Silver Spring). 21: 185-92. PMID: 23505185
- Anti-thrombosis effect of LRRFIP1 shRNA lentivirus in a mouse model of deep vein thrombosis. | Yin, X., et al. 2013. Thromb Res. 132: 127-31. PMID: 23751182
- The microRNA miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia. | Choe, N., et al. 2013. Atherosclerosis. 229: 348-55. PMID: 23880186
- Noncoding RNAs and LRRFIP1 regulate TNF expression. | Shi, L., et al. 2014. J Immunol. 192: 3057-67. PMID: 24567534
- Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and β-catenin signaling pathways. | Gubern, C., et al. 2014. Neuroscience. 268: 48-65. PMID: 24637094
- LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes. | Liu, Y., et al. 2015. Hepat Mon. 15: e28473. PMID: 26045710
- The clinical significance and oncogenic function of LRRFIP1 in pancreatic cancer. | Li, J., et al. 2024. Discov Oncol. 15: 123. PMID: 38634978
- Analysis of TNS3-203 and LRRFIP1-211 Transcripts as Oral Cancer Biomarkers. | Zeljic, K., et al. 2025. J Oral Pathol Med. 54: 151-160. PMID: 39888120
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRRFIP1 Antibody (32) | sc-135917 | 50 µg/0.5 ml | $322.00 |