LRRC48 Antibody (H-5): sc-390106

LRRC48 Antibody (H-5) is a mouse monoclonal IgG3 kappa light chain antibody that detects LRRC48 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-LRRC48 antibody (H-5) is available as non-conjugated format. LRRC48 consists of 523 amino acids, features five leucine-rich repeats and one LRRCT domain, and is encoded by human chromosome 17p11.2. The leucine-rich repeat (LRR) motifs play a crucial role in mediating protein-protein interactions, which are essential for various cellular processes, including innate immunity and nervous system development. The structural integrity of these motifs allows them to form a hydrophobic α/β horseshoe fold, accommodating multiple leucine residues within a tightly packed core. This unique structure not only facilitates the binding of diverse proteins but also contributes to the functional versatility of LRR-containing proteins. Importantly, mutations in genes encoding these proteins have been linked to several human diseases, highlighting LRRC48′s significance in maintaining cellular homeostasis and potential role in disease mechanisms.

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LRRC48 Antibody (H-5) References:

1. Molecular cloning of a novel membrane glycoprotein, pal, specifically expressed in photoreceptor cells of the retina and containing leucine-rich repeat.  |  Gomi, F., et al. 2000. J Neurosci. 20: 3206-13. PMID: 10777785
2. Lack of blood-brain barrier properties in microvessels of the prelaminar optic nerve head.  |  Hofman, P., et al. 2001. Invest Ophthalmol Vis Sci. 42: 895-901. PMID: 11274064
3. The leucine-rich repeat as a protein recognition motif.  |  Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
4. Vascular leucocyte adhesion molecules unaltered in the human retina in diabetes.  |  Hughes, JM., et al. 2004. Br J Ophthalmol. 88: 566-72. PMID: 15031178
5. Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina.  |  Kuiper, EJ., et al. 2004. Br J Ophthalmol. 88: 1082-7. PMID: 15258030
6. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases.  |  Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRRC48 Antibody (H-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LRRC48 Antibody (H-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRRC48 Antibody (H-5) Specifications

Alternate Product Name: LRRC48

Product Clone Name: H-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-27

Epitope Target: LRRC48

Epitope Species: human

Product Reactivity/Detection: LRRC48

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LRRC48 Antibody (H-5): P: Blocking Peptide