LRRC25 Antibody (E-7): sc-514216

LRRC25 Antibody (E-7) is a mouse monoclonal IgM antibody that detects LRRC25 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LRRC25 antibody (E-7) is available as the non-conjugated monoclonal isotype antibody. LRRC25, also known as leucine-rich repeat-containing protein 25 or MAPA (monocyte and plasmacytoid-activated protein), consists of 305 amino acids and features two leucine-rich repeats (LRRs). These LRRs provide a versatile structural framework facilitating protein-protein interactions, essential for various biological processes, including immune responses and cellular signaling. LRRC25 is predominantly expressed in monocyte-derived dendritic cells, granulocytes, monocytes, plasmacytoid dendritic cells, B-lymphocytes, and peripheral blood leukocytes, with lower expression levels found in the spleen, bone marrow, lymph nodes, fetal liver, and appendix. Expression of LRRC25 in these immune cell types suggests a potential role in the activation and regulation of both innate and acquired immunity, making LRRC25 a significant target for research in immunology and related fields.

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LRRC25 Antibody (E-7) References:

1. The leucine-rich repeat as a protein recognition motif.  |  Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
2. Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5.  |  Suzuki, T., et al. 2002. Epilepsy Res. 50: 265-75. PMID: 12200217
3. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.  |  Rissoan, MC., et al. 2002. Blood. 100: 3295-303. PMID: 12384430
4. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases.  |  Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
5. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.  |  Svendsen, JM., et al. 2009. Cell. 138: 63-77. PMID: 19596235

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRRC25 Antibody (E-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LRRC25 Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRRC25 Antibody (E-7) Specifications

Alternate Product Name: LRRC25

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 114-133

Epitope Target: LRRC25

Epitope Species: human

Product Reactivity/Detection: LRRC25

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LRRC25 Antibody (E-7): N/A