LRP5 Antibody (B-9): sc-390267

LRP5 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects LRP5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRP5 Antibody (B-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LRP5 plays a crucial role as a Wnt coreceptor, facilitating the binding of Wnt ligands to their receptors and thereby regulating the canonical Wnt signaling pathway, which is essential for various biological processes, including cell proliferation, differentiation, and bone development. LRP5 is expressed in the tibia of rats in regions associated with bone remodeling, highlighting its importance in skeletal health. Mutations in LRP5 can lead to the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG), underscoring LRP5′s significance in maintaining bone mass and integrity. The gene encoding LRP5 is located on human chromosome 11q13.4, and unique structural features, including a distinct arrangement of epidermal growth factor-like and low-density lipoprotein receptor repeats, set LRP5 apart from other members of the low-density lipoprotein receptor gene family, which includes proteins such as LDLR, Megalin, and VLDLR.

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LRP5 Antibody (B-9) References:

1. Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human.  |  Chen, D., et al. 1999. Genomics. 55: 314-21. PMID: 10049586
2. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.  |  Trommsdorff, M., et al. 1999. Cell. 97: 689-701. PMID: 10380922
3. Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms.  |  Mikhailenko, I., et al. 1999. J Cell Sci. 112 (Pt 19): 3269-81. PMID: 10504332
4. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.  |  Mao, J., et al. 2001. Mol Cell. 7: 801-9. PMID: 11336703
5. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.  |  Gong, Y., et al. 2001. Cell. 107: 513-23. PMID: 11719191
6. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.  |  Little, RD., et al. 2002. Am J Hum Genet. 70: 11-9. PMID: 11741193
7. PCSK9 and LRP5 in macrophage lipid internalization and inflammation.  |  Badimon, L., et al. 2021. Cardiovasc Res. 117: 2054-2068. PMID: 32991689
8. LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway.  |  Zhou, H., et al. 2022. J Cell Mol Med. 26: 2981-2994. PMID: 35429093
9. B7-1 mediates podocyte injury and glomerulosclerosis through communication with Hsp90ab1-LRP5-β-catenin pathway.  |  Li, J., et al. 2022. Cell Death Differ. 29: 2399-2416. PMID: 35710882
10. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.  |  Pilat, JM., et al. 2023. J Clin Invest. 133: PMID: 37166989
11. LRP5, Bone Mass Polymorphisms and Skeletal Disorders.  |  Littman, J., et al. 2023. Genes (Basel). 14: PMID: 37895195
12. Cloning of a novel member of the low-density lipoprotein receptor family.  |  Hey, PJ., et al. 1998. Gene. 216: 103-11. PMID: 9714764

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRP5 Antibody (B-9) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-LRP5 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRP5 Antibody (B-9) Specifications

Alternate Product Name: LRP5

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1417-1455

Epitope Target: LRP5

Epitope Species: human

Product Reactivity/Detection: LRP5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for LRP5 Antibody (B-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin