LRP Antibody (F-7): sc-390141

LRP Antibody (F-7) is a mouse monoclonal IgG1 antibody that detects LRP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRP, also known as the major vault protein (MVP), plays a crucial role in the multidrug resistance (MDR) phenotype observed in tumor cells, which often leads to treatment failure in cancer therapy. LRP is primarily located in the cytoplasm and is a key component of multimeric ribonucleoprotein complexes that transport untranslated RNA along cytoskeletal tracks, facilitating cellular processes essential for maintaining cellular homeostasis and drug transport. LRP expression in various multidrug-resistant cancer cell lines and clinical samples highlights its significance in mediating drug resistance, potentially through transport mechanisms. Additionally, LRP has two alternative splice variants, with the long-LRP isoform being ubiquitously expressed across many normal tissues, indicating a fundamental role in cellular function. The unique structural features of LRP, including a TATA-less promoter and specific binding sites, further underscore its importance in gene regulation and expression, making anti-LRP antibody (F-7) an invaluable tool for researchers studying drug resistance and related pathways in cancer biology.

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LRP Antibody (F-7) References:

1. The 16p11 breakpoint in myxoid liposarcomas might affect the expression of the LRP gene on 16p11.2 encoding the multidrug resistance associated major vault protein.  |  Plaat, BE., et al. 2000. Eur J Clin Invest. 30: 447-53. PMID: 10809905
2. Selection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein.  |  Scheffer, GL., et al. 2002. Br J Cancer. 86: 954-62. PMID: 11953829
3. Overexpression of the human major vault protein in gangliogliomas.  |  Aronica, E., et al. 2003. Epilepsia. 44: 1166-75. PMID: 12919388
4. Expression and proteasomal degradation of the major vault protein (MVP) in mammalian oocytes and zygotes.  |  Sutovsky, P., et al. 2005. Reproduction. 129: 269-82. PMID: 15749954
5. Tumor expression of major vault protein is an adverse prognostic factor for radiotherapy outcome in oropharyngeal carcinoma.  |  Silva, P., et al. 2007. Int J Radiat Oncol Biol Phys. 69: 133-40. PMID: 17459603
6. Hyperosmotic stress up-regulates the expression of major vault protein in SW620 human colon cancer cells.  |  Ikeda, R., et al. 2008. Exp Cell Res. 314: 3017-26. PMID: 18671966
7. In silico resurrection of the major vault protein suggests it is ancestral in modern eukaryotes.  |  Daly, TK., et al. 2013. Genome Biol Evol. 5: 1567-83. PMID: 23887922
8. Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis.  |  Lötsch, D., et al. 2013. Oncotarget. 4: 1904-18. PMID: 24243798
9. Inactivation of the Cytoprotective Major Vault Protein by Caspase-1 and -9 in Epithelial Cells during Apoptosis.  |  Grossi, S., et al. 2020. J Invest Dermatol. 140: 1335-1345.e10. PMID: 31877317
10. Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.  |  Ramberg, H., et al. 2021. Carcinogenesis. 42: 685-693. PMID: 33609362

The preferred LRP antibody is LRP Antibody (1014): sc-23916.