LRP Antibody (42): sc-135975
- LRP Antibody (42) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 403-592 of LRP of human origin
- recommended for detection of LRP of human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LRP Antibody (42). This work is in progress.
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SEE ALSO...
LRP Antibody (42) is a mouse monoclonal IgG1 antibody that detects LRP in human and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). LRP, also known as the major vault protein (MVP), plays a crucial role in mediating multidrug resistance in tumor cells, which is a significant challenge in cancer treatment. LRP is primarily located in the cytoplasm and is a key component of multimeric ribonucleoprotein complexes that transport untranslated RNA along cytoskeletal tracks, facilitating cellular processes essential for maintaining cellular homeostasis and drug transport. The presence of LRP in various multidrug-resistant cancer cell lines and clinical samples highlights its importance in understanding the mechanisms of drug resistance, as LRP overexpression can lead to therapeutic failure. LRP′s unique structure, characterized by two alternative splice variants, allows for diverse functional roles within different tissues, making LRP a vital target for research aimed at overcoming drug resistance in cancer therapy. Anti-LRP antibody (42) is an invaluable tool for researchers investigating the complexities of drug resistance and the underlying mechanisms of LRP in both human and canine models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRP Antibody (42) References:
- Recombinant major vault protein is targeted to neuritic tips of PC12 cells. | Herrmann, C., et al. 1999. J Cell Biol. 144: 1163-72. PMID: 10087261
- Major vault protein/lung resistance-related protein (MVP/LRP) expression in nervous system tumors. | Sasaki, T., et al. 2002. Brain Tumor Pathol. 19: 59-62. PMID: 12622134
- Direct activation of the human major vault protein gene by DNA-damaging agents. | Shimamoto, Y., et al. 2006. Oncol Rep. 15: 645-52. PMID: 16465425
- Upregulation of breast cancer resistance protein and major vault protein in drug resistant epilepsy. | Banerjee Dixit, A., et al. 2017. Seizure. 47: 9-12. PMID: 28273590
- Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas. | Lee, HM., et al. 2017. Sci Rep. 7: 13201. PMID: 29038587
- Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity. | Yu, H., et al. 2020. Hepatology. 72: 518-534. PMID: 31758709
- The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. | Slovak, ML., et al. 1995. Cancer Res. 55: 4214-9. PMID: 7671223
- Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues. | Dingemans, AM., et al. 1996. Ann Oncol. 7: 625-30. PMID: 8879378
- Expression of the human major vault protein LRP in acute myeloid leukemia. | Hart, SM., et al. 1997. Exp Hematol. 25: 1227-32. PMID: 9357965
- Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues. | Schroeijers, AB., et al. 1998. Am J Pathol. 152: 373-8. PMID: 9466563
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRP Antibody (42) | sc-135975 | 50 µg/0.5 ml | $322.00 |