LRG1 Antibody (C-8): sc-390921
- LRG1 Antibody (C-8) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 246-295 near the C-terminus of LRG1 of mouse origin
- recommended for detection of LRG1 of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for LRG1 Antibody (C-8) for WB applications. This reagent is now offered in a bundle with LRG1 Antibody (C-8) (see ordering information below).
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LRG1 Antibody (C-8) is a mouse monoclonal IgG3 antibody that detects LRG1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRG1, or leucine-rich alpha-2-glycoprotein, is a 347 amino acid secreted protein characterized by eight leucine-rich repeats and one LRRCT domain, which play a crucial role in mediating protein-protein interactions, signal transduction, cell adhesion, and developmental processes. LRG1 is predominantly found in plasma and is notably expressed during granulocyte differentiation, highlighting its importance in immune response and inflammation. The gene encoding LRG1 is located on human chromosome 19p13.3, a region known for its high gene density, containing approximately 1,400 genes, including several members of the immunoglobulin superfamily. This chromosomal location houses genes vital for immune function, such as killer cell and leukocyte immunoglobulin-like receptors, as well as various intercellular adhesion molecules. The intricate structure of LRG1, with multiple leucine-rich repeats, not only facilitates diverse biological functions but also underscores potential as a biomarker in various pathological conditions, making anti-LRG1 antibody (C-8) an essential tool for researchers studying immune responses and related diseases.
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LRG1 Antibody (C-8) References:
- LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. | Wang, X., et al. 2013. Nature. 499: 306-11. PMID: 23868260
- LRG1 Promotes Diabetic Kidney Disease Progression by Enhancing TGF-β-Induced Angiogenesis. | Hong, Q., et al. 2019. J Am Soc Nephrol. 30: 546-562. PMID: 30858225
- LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. | O'Connor, MN., et al. 2021. Med. 2: 1231-1252.e10. PMID: 35590198
- Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation. | Yang, J., et al. 2023. Exp Mol Med. 55: 1013-1022. PMID: 37121976
- LRG1 predicts the prognosis and is associated with immune infiltration in thyroid cancer: a bioinformatics study. | Fu, Z., et al. 2024. Endocr Connect. 13: PMID: 37991216
- Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles. | Jiang, W., et al. 2024. Theranostics. 14: 1049-1064. PMID: 38250043
- Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth. | Gao, M., et al. 2024. Oncogenesis. 13: 21. PMID: 38871685
- LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate diabetic kidney disease. | Wang, X., et al. 2024. Mol Ther. 32: 3177-3193. PMID: 38910328
- Endothelial RUNX3 controls LSEC dysfunction and angiocrine LRG1 signaling to prevent liver fibrosis. | Ojha, U., et al. 2024. Hepatology.. PMID: 39042837
- Targeted degradation of LRG1 to attenuate renal fibrosis. | Fan, L., et al. 2024. Asian J Pharm Sci. 19: 100941. PMID: 39246511
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRG1 Antibody (C-8) | sc-390921 | 200 µg/ml | $322.00 | |||
LRG1 Antibody (C-8): m-IgG3 BP-HRP Bundle | sc-550486 | 200 µg Ab; 40 µg BP | $361.00 | |||
LRG1 (C-8) Neutralizing Peptide | sc-390921 P | 100 µg/0.5 ml | $69.00 |