Molecular structure of LP 44, CAS Number: 824958-12-5
LP 44 (CAS 824958-12-5)
Alternate Names:
4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride
Application:
LP 44 is a high affinity SR-7 agonist
CAS Number:
824958-12-5
Purity:
≥98%
Molecular Weight:
488.13
Molecular Formula:
C27H37N3OS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LP 44 is a high affinity 5-HT7 receptor agonist. Ki = 0.22 nM. LP44 displays selectivity over 5-HT1A and 5-HT2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
LP 44 (CAS 824958-12-5) References
- The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. | Monti, JM., et al. 2008. Behav Brain Res. 191: 184-9. PMID: 18466985
- Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway. | Xu, Y., et al. 2011. Neuroscience. 182: 71-81. PMID: 21371532
- 5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission. | Costa, L., et al. 2012. Hippocampus. 22: 790-801. PMID: 21538661
- Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon. | Meurs, L., et al. 2011. PLoS One. 6: e24393. PMID: 21931706
- 5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors. | Eriksson, TM., et al. 2012. Neuropharmacology. 63: 1150-60. PMID: 22801295
- The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia. | Yesilyurt, O., et al. 2015. Eur J Pharmacol. 762: 402-10. PMID: 25917322
- Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model. | Wu, L., et al. 2016. J Gastroenterol. 51: 1040-1049. PMID: 26984549
- Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice. | Demirkaya, K., et al. 2016. J Appl Oral Sci. 24: 218-22. PMID: 27383702
- Evaluation of 5-HT7 Receptor Trafficking on In Vivo and In Vitro Model of Lipopolysaccharide (LPS)-Induced Inflammatory Cell Injury in Rats and LPS-Treated A549 Cells. | Ayaz, G., et al. 2017. Biochem Genet. 55: 34-47. PMID: 27586707
- Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. | Snider, MA., et al. 2018. J Anim Sci. 96: 1570-1578. PMID: 29471490
- Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide. | Arreola-Peralta, LD., et al. 2018. Peptides. 105: 1-6. PMID: 29730242
- The serotonin (5-hydroxytryptamine) 5-HT7 receptor is up-regulated in Onuf's nucleus in rats with chronic spinal cord injury. | Ni, J., et al. 2019. BJU Int. 123: 718-725. PMID: 29781566
- The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction. | Cinar, I., et al. 2020. Hum Exp Toxicol. 39: 1005-1018. PMID: 32329363
Activator of:
SR-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LP 44, 10 mg | sc-224044 | 10 mg | $119.00 | |||
LP 44, 50 mg | sc-224044A | 50 mg | $680.00 |