Molecular structure of Lovastatin Hydroxy Acid, Sodium Salt, CAS Number: 75225-50-2
Lovastatin Hydroxy Acid, Sodium Salt (CAS 75225-50-2)
See product citations (4)
Alternate Names:
Lovastatin EP Impurity B
Application:
Lovastatin Hydroxy Acid, Sodium Salt is an HMGCR inhibitor
CAS Number:
75225-50-2
Purity:
≥95%
Molecular Weight:
444.54
Molecular Formula:
C24H37NaO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lovastatin Hydroxy Acid, Sodium Salt is an active carboxylate form of Lovastatin (sc-200850), an inhibitor of HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM). Lovastatin Hydroxy Acid, Sodium Salt is active in whole cells as well as cell-free assays and inhibits cholesterol and isoprenoid biosynthesis. Lovastatin also blocks protein isoprenylation, reduces plasma cholesterol levels in humans, and causes cells to arrest early in the G1 phase.
Lovastatin Hydroxy Acid, Sodium Salt (CAS 75225-50-2) References
- Determination of lovastatin hydroxy acid in female B6C3F1 mouse serum. | Lodge, JW., et al. 2008. J Anal Toxicol. 32: 248-52. PMID: 18397577
- In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities. | Fukami, T., et al. 2010. Drug Metab Dispos. 38: 2173-8. PMID: 20810539
- Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis. | Riedmaier, S., et al. 2011. Front Pharmacol. 2: 41. PMID: 21852972
- Use of a green (bio) solvent--limonene--as extractant and immiscible diluent for large volume injection in the RPLC-tandem MS assay of statins and related metabolites in human plasma. | Medvedovici, A., et al. 2013. Biomed Chromatogr. 27: 48-57. PMID: 22511331
- Short-term high-dose effect of lovastatin on thrombolysis by rt-PA in a human whole-blood in vitro clot model. | Kandadai, MA., et al. 2012. Curr Neurovasc Res. 9: 207-13. PMID: 22621227
- The role of acid-base imbalance in statin-induced myotoxicity. | Taha, DA., et al. 2016. Transl Res. 174: 140-160.e14. PMID: 27083388
- In vitro antibacterial effects of statins against bacterial pathogens causing skin infections. | Ko, HHT., et al. 2018. Eur J Clin Microbiol Infect Dis. 37: 1125-1135. PMID: 29569046
- Comprehensive chemical profiling of monascus-fermented rice product and screening of lipid-lowering compounds other than monacolins. | Liang, JX., et al. 2019. J Ethnopharmacol. 238: 111879. PMID: 30991138
- Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry. | Meola, TR., et al. 2020. Eur J Pharm Sci. 150: 105357. PMID: 32446169
- A safety, tolerability, and pharmacokinetic study of a novel simvastatin silica-lipid hybrid formulation in healthy male participants. | Meola, TR., et al. 2021. Drug Deliv Transl Res. 11: 1261-1272. PMID: 32918160
- Simultaneous screening of dietary supplements for 25 anti-hyperlipidemic substances using ultra-performance liquid chromatography and liquid chromatography/electrospray ionization tandem mass spectrometry. | Kim, NS., et al. 2021. Rapid Commun Mass Spectrom. 35: e8989. PMID: 33105026
- Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability. | Faris, TM., et al. 2020. Saudi Pharm J. 28: 1851-1867. PMID: 33424274
- Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach. | Barbarossa, A., et al. 2022. Antibiotics (Basel). 11: PMID: 35740222
Inhibitor of:
HMGCR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lovastatin Hydroxy Acid, Sodium Salt, 10 mg | sc-215265 | 10 mg | $265.00 |