Molecular structure of Losartan Potassium, CAS Number: 124750-99-8
Losartan Potassium (CAS 124750-99-8)
See product citations (10)
Alternate Names:
Losartan Potassium is known as a potent, synthetic AT1 receptor antagonist.
Application:
Losartan Potassium is a specific antagonist of the AT1 receptor with significant downstream effects.
CAS Number:
124750-99-8
Purity:
≥99%
Molecular Weight:
461.01
Molecular Formula:
C22H22ClKN6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor by Losartan Potassium and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism via Losartan Potassium has other downstream effects, including a correlated antagonism of the thromboxane A2 receptor, inhibition of platelet aggregation, and induction of peroxisome proliferator-actived receptor gamma (PPARgamma) activity.
Losartan Potassium (CAS 124750-99-8) References
- International union of pharmacology. XXIII. The angiotensin II receptors. | de Gasparo, M., et al. 2000. Pharmacol Rev. 52: 415-72. PMID: 10977869
- Angiotensin II receptor antagonist losartan has persistent effects on blood pressure in the young spontaneously hypertensive rat: lack of relation to vascular structure. | Morton, JJ., et al. 1992. J Vasc Res. 29: 264-9. PMID: 1387008
- Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function. | Wong, PC., et al. 1992. Hypertension. 19: 663-7. PMID: 1592464
- Losartan, a specific angiotensin II receptor antagonist, increases angiotensin I and angiotensin II release from isolated rat hind legs: evidence for locally regulated renin-angiotensin system in vascular tissue. | Mizuno, K., et al. 1992. Life Sci. 50: PL209-14. PMID: 1598061
- Molecular-specific effects of angiotensin II antagonists: clinical relevance to treating hypertension? | Reid, JL. 2005. J Renin Angiotensin Aldosterone Syst. 6: 15-24. PMID: 16088847
- Quantification of Losartan Potassium Polymorphs Using Powder X-Ray Diffraction. | Lou, Y. and Zuo, L. 2021. J AOAC Int. 104: 579-584. PMID: 33337486
- Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels. | Reque, R., et al. 2021. Environ Toxicol Pharmacol. 87: 103727. PMID: 34454063
- Synthesis and Characterization of Nanoporous Carbon Carriers for Losartan Potassium Delivery. | Ejsmont, A., et al. 2021. Materials (Basel). 14: PMID: 34885515
- Quantitative analysis of solid dosage forms of Losartan potassium by Raman spectroscopy. | Shafaq, S., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 272: 120996. PMID: 35149485
- Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa. | Elezaj, V., et al. 2022. Pharmaceutics. 14: PMID: 35335946
- Losartan Interactions with 2-Hydroxypropyl-β-CD. | Palli, V., et al. 2022. Molecules. 27: PMID: 35458617
- Effect of losartan potassium, metformin hydrochloride, and simvastatin on in vitro bioaccessibility of Cu, Fe, Mn, and Zn in oat flour from Brazil. | de Carvalho, WC., et al. 2022. J Trace Elem Med Biol. 73: 127032. PMID: 35797925
- Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression. | Luo, Q., et al. 2022. Pharmaceutics. 14: PMID: 36015367
- Losartan Potassium and Verapamil Hydrochloride Compound Transdermal Drug Delivery System: Formulation and Characterization. | Chen, YS., et al. 2022. Int J Mol Sci. 23: PMID: 36361834
- Degradation of Losartan Potassium Highlighted by Correlated Studies of Photoluminescence, Infrared Absorption Spectroscopy and Dielectric Spectroscopy. | Paraschiv, M., et al. 2022. Pharmaceutics. 14: PMID: 36365237
Inhibitor of:
AT1, Olfr611, Olfr615, Olfr616, Olfr617, Olfr618, and RGMc.Activator of:
Adrenomedullin (ADM), CTL5, HEM1, Hemoglobin ε, HNF-1α, IRR, Phocein, and XTES.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Losartan Potassium, 1 g | sc-204796 | 1 g | $54.00 | |||
Losartan Potassium, 5 g | sc-204796A | 5 g | $126.00 | |||
Losartan Potassium, 25 g | sc-204796B | 25 g | $385.00 | |||
Losartan Potassium, 100 g | sc-204796C | 100 g | $1051.00 |