Losartan-d4 Carboxylic Acid (CAS 1246820-62-1)

Losartan-d4 Carboxylic Acid is a deuterium-labeled analog of Losartan′s active metabolite, specifically engineered for its role in pharmacokinetic and metabolic studies. This compound incorporates deuterium atoms in place of hydrogen, which significantly alters its physical properties without changing its chemical nature. The inclusion of deuterium allows for a marked improvement in the detection and quantification of the compound in complex biological matrices, utilizing mass spectrometry techniques. This characteristic is pivotal in research focused on elucidating the metabolic pathways of Losartan and its metabolites, providing insights into the compound′s biotransformation processes. Losartan-d4 Carboxylic Acid serves as an invaluable tool in the development of analytical methods aimed at understanding the dynamics of drug metabolism and disposition. Its utility extends to the field of drug development, where it aids in the characterization of pharmacokinetic profiles, offering a deeper understanding of the drug′s behavior in biological systems.