Molecular structure of Losartan-d4, CAS Number: 1030937-27-9
Losartan-d4 (CAS 1030937-27-9)
Alternate Names:
2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5yl)[1,1′-biphenyl-d4]-4-yl]methyl]-1H-imidazole-5-methanol; Cozaar-d4
Application:
Losartan-d4 is a deuterium-labelled analog of Losartan
CAS Number:
1030937-27-9
Molecular Weight:
426.94
Molecular Formula:
C22H19D4ClN6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Losartan-d4 is a deuterium-labeled version of Losartan, a nonpeptide angiotensin II AT1-receptor antagonist. This compound prevents the signal cascade initiated by angiotensin II binding to the receptor, thus inhibiting vasoconstriction and in turn increasing capillary blood volume. This compound is useful in kinetic isotope effect studies and as an internal standard in NMR experiments.
Losartan-d4 (CAS 1030937-27-9) References
- Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study. | Choi, Y., et al. 2016. Drug Des Devel Ther. 10: 3021-3028. PMID: 27703330
- Online extraction of antihypertensive drugs and their metabolites from untreated human serum samples using restricted access carbon nanotubes in a column switching liquid chromatography system. | de Faria, HD., et al. 2017. J Chromatogr A. 1528: 41-52. PMID: 29102378
- An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity. | Sreevatsav Adiraju, SK., et al. 2018. Bioanalysis. 10: 1577-1590. PMID: 30226084
- A Dilute-and-Shoot LC-MS/MS Method for Screening of 43 Cardiovascular Drugs in Human Urine. | Pham, T. V., Lee, G., Mai, X. L., Le, T. A. T., Nguyen, T. N. V., Hong, J., & Kim, K. H. (2021). Mass Spectrometry Letters,. 12(1),: 1-10.
Inhibitor of:
AT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Losartan-d4, 1 mg | sc-280936 | 1 mg | $400.00 |