Molecular structure of Losartan-d3 Carboxylic Acid
Losartan-d3 Carboxylic Acid
Application:
Losartan-d3 Carboxylic Acid is a deuterium-labelled Losartan metabolite
Molecular Weight:
439.91
Molecular Formula:
C22H18D3ClN6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Losartan-d3 Carboxylic Acid is a isotopically labeled metabolite of Losartan, a nonpeptide angiotensin II AT1-receptor antagonist. This compound prevents the signal cascade initiated by angiotensin II binding to the receptor, thus inhibiting vasoconstriction and in turn increasing capillary blood volume. This compound is useful in kinetic isotope effect studies and as an internal standard in NMR experiments.
Losartan-d3 Carboxylic Acid References
- Angiotensin II receptor antagonists. From discovery to antihypertensive drugs. | Timmermans, PB., et al. 1991. Hypertension. 18: III136-42. PMID: 1937677
- Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones. | Chang, LL., et al. 1993. J Med Chem. 36: 2558-68. PMID: 8355255
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Losartan-d3 Carboxylic Acid, 1 mg | sc-280935 | 1 mg | $380.00 |