Molecular structure of Losartan carboxylic acid, CAS Number: 124750-92-1
Losartan carboxylic acid (CAS 124750-92-1)
See product citations (18)
Alternate Names:
2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid
Application:
Losartan carboxylic acid is a metabolite of Losartan
CAS Number:
124750-92-1
Molecular Weight:
436.89
Molecular Formula:
C22H21ClN6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Losartan Carboxylic Acid is a metabolite of losartan (sc-353662), an angiotensin II receptor, type 1 (AT1) antagonist. Losartan carboxylic acid has been extensively studied in in vitro experiments, primarily examining its impact on cell cultures, biochemical assays, and gene expression. The findings of these studies have revealed that losartan carboxylic acid possesses the ability to inhibit the growth of cancer cells, regulate gene expression, and reduce inflammation.
Losartan carboxylic acid (CAS 124750-92-1) References
- Angiotensin II receptor antagonists. From discovery to antihypertensive drugs. | Timmermans, PB., et al. 1991. Hypertension. 18: III136-42. PMID: 1937677
- Liquid chromatography-mass spectrometric determination of losartan and its active metabolite on dried blood spots. | Rao, RN., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 902: 47-54. PMID: 22770781
- Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes. | Dorado, P., et al. 2012. Drug Metabol Drug Interact. 27: 217-33. PMID: 23093260
- Simultaneous determination of losartan, losartan acid and amlodipine in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. | Karra, VK., et al. 2012. Pharm Methods. 3: 18-25. PMID: 23781473
- Simultaneous LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 substrate drugs and their metabolites. | Tanaka, S., et al. 2014. Biol Pharm Bull. 37: 18-25. PMID: 24389476
- Simultaneous Determination and Pharmacokinetics of Metolazone, Losartan and Losartan Carboxylic Acid in Rat Plasma by HPLC-ESI-MS-MS. | Dubey, R., et al. 2015. J Chromatogr Sci. 53: 1520-7. PMID: 25947361
- Human bioequivalence evaluation of two losartan potassium tablets under fasting conditions. | Das, AK., et al. 2015. Indian J Pharm Sci. 77: 190-5. PMID: 26009652
- Simultaneous Determination and Pharmacokinetic Study of Losartan, Losartan Carboxylic Acid, Ramipril, Ramiprilat, and Hydrochlorothiazide in Rat Plasma by a Liquid Chromatography/Tandem Mass Spectrometry Method. | Dubey, R. and Ghosh, M. 2015. Sci Pharm. 83: 107-24. PMID: 26839805
- Conjugation to Ascorbic Acid Enhances Brain Availability of Losartan Carboxylic Acid and Protects Against Parkinsonism in Rats. | Subudhi, BB., et al. 2018. AAPS J. 20: 110. PMID: 30350232
- Target quantification of azole antifungals and retrospective screening of other emerging pollutants in wastewater effluent using UHPLC -QTOF-MS. | Assress, HA., et al. 2019. Environ Pollut. 253: 655-666. PMID: 31330357
- Evaluation and analytical applicability of a novel volumetric absorptive microsampling strategy for adherence monitoring of antihypertensive drugs by means of LC-HRMS/MS. | Jacobs, CM., et al. 2021. Anal Chim Acta. 1187: 339137. PMID: 34753562
- Sartan blood pressure regulators in classical and biofilm wastewater treatment - Concentrations and metabolism. | Li, R., et al. 2023. Water Res. 229: 119352. PMID: 36450176
- Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones. | Chang, LL., et al. 1993. J Med Chem. 36: 2558-68. PMID: 8355255
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Losartan carboxylic acid, 10 mg | sc-218661 | 10 mg | $200.00 |