Losartan Carboxaldehyde-d3 (CAS 1184999-26-5)

Losartan Carboxaldehyde-d3 is an isotopologue of Losartan Carboxaldehyde, distinguished by the incorporation of three deuterium atoms, which are heavy isotopes of hydrogen. This modification enhances its utility in scientific studies, particularly in the field of pharmacokinetics and drug metabolism, by allowing researchers to track and analyze the molecule′s behavior and transformation within complex biological systems more precisely. The presence of deuterium atoms does not significantly alter the chemical properties of the molecule compared to its non-deuterated counterpart, but it provides a tool for mass spectrometry and NMR spectroscopy by offering distinct signals that can be clearly attributed to the isotopologue. This makes Losartan Carboxaldehyde-d3 invaluable in elucidating pathways of drug metabolism and in the development of more effective and specific drug molecules, as it helps in understanding the intricate mechanisms by which drug molecules are processed within organisms. The use of such deuterated compounds is a cornerstone in the precise quantification of drug and metabolite concentrations in various tissues, contributing significantly to the optimization of pharmacological profiles of new drug candidates.