Loreclezole hydrochloride (CAS 117857-45-1)
Available in US only.
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Loreclezole hydrochloride is a subtype-selective GABAA receptor agonist. Positive allosteric modulator of beta2 or beta3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric rho1 GABAC receptors. Loreclezole hydrochloride, a synthetic benzimidazole derivative, has undergone extensive investigation as a potential therapeutic solution for diverse medical conditions. Despite its potential, the exact mechanism through which Loreclezole hydrochloride operates remains a mystery. Nevertheless, there is a prevailing notion that Loreclezole hydrochloride functions by curtailing the activity of cyclooxygenase (COX) enzymes, pivotal in generating pro-inflammatory agents. Additionally, Loreclezole hydrochloride has demonstrated the capability to impede nuclear factor-kappa B (NF-kB) activity, which governs the orchestration of inflammatory reactions.
Loreclezole hydrochloride (CAS 117857-45-1) References
- Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents. | Donnelly, JL. and MacDonald, RL. 1996. Neuropharmacology. 35: 1233-41. PMID: 9014138
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Loreclezole hydrochloride, 1 mg | sc-204061 | 1 mg | $195.00 | |||
| US: Only available in the US | ||||||
Loreclezole hydrochloride, 5 mg | sc-204061A | 5 mg | $849.00 | |||
| US: Only available in the US | ||||||