Molecular structure of Lomerizine Hydrochloride, CAS Number: 101477-54-7
Lomerizine Hydrochloride (CAS 101477-54-7)
See product citations (1)
Alternate Names:
1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine Hydrochloride Terranas Migsis
Application:
Lomerizine Hydrochloride is a calcium channel protein inhibitor
CAS Number:
101477-54-7
Purity:
≥99%
Molecular Weight:
541.47
Molecular Formula:
C27H30F2N2O3•2HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Lomerizine Hydrochloride is a calcium channel protein inhibitor. Lomerizine hydrochloride is a compound known for its ability to inhibit voltage-activated inward calcium currents. At a concentration of 1 μM, it has been observed to effectively reduce neurotoxicity induced by glutamate, NMDA, or kainate in rat retinal primary cell cultures. Furthermore, it exhibits selectivity as a cerebral vasodilator.
Lomerizine Hydrochloride (CAS 101477-54-7) References
- Short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA). | Tada, Y., et al. 2009. Intern Med. 48: 2141-4. PMID: 20009409
- [A case of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in which lomerizine hydrochloride was suggested to prevent recurrent stroke]. | Shimizu, H., et al. 2014. Rinsho Shinkeigaku. 54: 22-6. PMID: 24429644
- Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors. | Yates, NJ., et al. 2017. Neural Regen Res. 12: 307-316. PMID: 28400815
- Basi-parallel anatomical scanning-magnetic resonance imaging for the diagnosis of reversible cerebral vasoconstriction syndrome of the basilar artery: a case report. | Yamamoto, A., et al. 2017. Acute Med Surg. 4: 458-461. PMID: 29123909
- Effectiveness of the traditional Japanese Kampo medicine Yokukansan for chronic migraine: A case report. | Akiyama, H. and Hasegawa, Y. 2019. Medicine (Baltimore). 98: e17000. PMID: 31490382
- A Nationwide Survey and Multicenter Registry-Based Database of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy in Japan. | Shindo, A., et al. 2020. Front Aging Neurosci. 12: 216. PMID: 32765252
- Effect of Lomerizine Hydrochloride on Preventing Strokes in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy. | Watanabe-Hosomi, A., et al. 2020. Clin Neuropharmacol. 43: 146-150. PMID: 32947425
- A case of reversible cerebral vasoconstriction syndrome associated with anti-phospholipid antibody syndrome and systemic lupus erythematosus. | Shima, A., et al. 2021. eNeurologicalSci. 24: 100351. PMID: 34258413
- Hemiplegic migraine type 2 with new mutation of the ATP1A2 gene in Japanese cases. | Oda, I., et al. 2022. Neurosci Res. 180: 83-89. PMID: 35257835
Inhibitor of:
Calcium Channel Protein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lomerizine Hydrochloride, 500 mg | sc-204795 | 500 mg | $89.00 | |||
Lomerizine Hydrochloride, 1 g | sc-204795A | 1 g | $190.00 |