Date published: 2026-1-10

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Lomefloxacin, Hydrochloride (CAS 98079-52-8)

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Alternate Names:
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Application:
Lomefloxacin, Hydrochloride is a Topo II antagonist
CAS Number:
98079-52-8
Molecular Weight:
387.81
Molecular Formula:
C17H19F2N3O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lomefloxacin, Hydrochloride is utilized in microbiology to study the efficacy and mechanism of antibacterial agents. Lomefloxacin, Hydrochloride is of interest due to its ability to inhibit bacterial DNA gyrase, making it useful for understanding bacterial replication and transcription processes. In the field of biochemistry, Lomefloxacin, Hydrochloride is used to explore the interactions between chemicals and bacterial enzymes, contributing to the development of novel strategies to combat bacterial resistance. Some also employ Lomefloxacin, Hydrochloride in studies focused on the kinetics and dynamics of fluoroquinolone action, aiding in the optimization of dosing regimens and the minimization of side effects. Its role in inducing phototoxicity is investigated under controlled laboratory conditions to ascertain the mechanisms underlying chemical-induced cellular responses to UV exposure.


Lomefloxacin, Hydrochloride (CAS 98079-52-8) References

  1. In vitro availability of lomefloxacin hydrochloride in presence of essential and trace elements.  |  Sultana, N., et al. 2005. Pak J Pharm Sci. 18: 59-65. PMID: 16380347
  2. Corneal critical barrier against the penetration of dexamethasone and lomefloxacin hydrochloride: evaluation by the activation energy for drug partition and diffusion in cornea.  |  Yasueda, S., et al. 2007. Drug Dev Ind Pharm. 33: 805-11. PMID: 17729097
  3. Sonodynamic effects of lomefloxacin derivatives conjugated with methoxy polyethylene glycol on sarcoma 180 cells.  |  Komori, C., et al. 2009. Anticancer Res. 29: 243-8. PMID: 19331156
  4. Enantioseparation of lomefloxacin hydrochloride by high-speed counter-current chromatography using sulfated-β-cyclodextrin as a chiral selector.  |  Wei, Y., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 2937-41. PMID: 20837406
  5. Design and evaluation of proniosomes as a carrier for ocular delivery of lomefloxacin HCl.  |  Khalil, RM., et al. 2017. J Liposome Res. 27: 118-129. PMID: 27079800
  6. Enhancement of lomefloxacin Hcl ocular efficacy via niosomal encapsulation: in vitro characterization and in vivo evaluation.  |  Khalil, RM., et al. 2017. J Liposome Res. 27: 312-323. PMID: 27241274
  7. Mucoadhesive niosomal in situ gel for ocular tissue targeting: in vitro and in vivo evaluation of lomefloxacin hydrochloride.  |  Abdelbary, A., et al. 2017. Pharm Dev Technol. 22: 409-417. PMID: 27476543
  8. Lomefloxacin Induces Oxidative Stress and Apoptosis in COLO829 Melanoma Cells.  |  Beberok, A., et al. 2017. Int J Mol Sci. 18: PMID: 29053584
  9. Analytical Eco-Scale for Assessing the Greenness of a Developed Potentiometric Method for Lomefloxacin Hydrochloride Determination in its Different Dosage Forms, Plasma, and Dissolution Medium.  |  Boltia, SA., et al. 2019. J AOAC Int. 102: 794-800. PMID: 30446018
  10. In vitro and in vivo activity of NY-198, a new difluorinated quinolone.  |  Hirose, T., et al. 1987. Antimicrob Agents Chemother. 31: 854-9. PMID: 3476021
  11. Determination of elemental impurities in lomefloxacin hydrochloride ear drops by inductively coupled plasma-mass spectrometry using oxygen reaction mode and study of their catalytic effect on photodegradation reaction.  |  Xu, B., et al. 2023. Rapid Commun Mass Spectrom. 37: e9468. PMID: 36597261
  12. Influence of electrolytes on the cloud point phenomenon of tween-80+ lomefloxacin hydrochloride mixtures and their thermodynamic parameters  |  Ahsan, S. M. A., Mahbub, S., Hoque, M. A., Khan, M. A., Kumar, D., Khan, J. M., & El-Sherbeeny, A. M. 2020. Journal of Molecular Liquids. 318: 113999.
  13. Magnetic cobalt ferrite biochar composite as peroxymonosulfate activator for removal of lomefloxacin hydrochloride  |  You, Y., Shi, Z., Li, Y., Zhao, Z., He, B., & Cheng, X. 2021. Separation and Purification Technology. 272: 118889.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lomefloxacin, Hydrochloride, 1 g

sc-218660
1 g
$55.00