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Lofepramine hydrochloride (CAS 26786-32-3)

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Alternate Names:
N-(4-Chlorobenzoylmethyl)-3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)-n-methylpropylamine hydrochloride
CAS Number:
26786-32-3
Molecular Weight:
455.42
Molecular Formula:
C26H28Cl2N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lofepramine hydrochloride is used in research studies that focus on understanding the mechanisms of action of antidepressants. It often serves as a tool in neuropharmacological studies to investigate the regulation of neurotransmitter systems, such as norepinephrine and serotonin. Researchers utilize lofepramine hydrochloride to study its effects on neurotransmitter reuptake mechanisms, which are central to its mode of action. Additionally, it is used in comparative studies to analyze its pharmacokinetics and metabolic pathways in relation to other compounds with similar mechanisms. The chemical′s role in modulating receptor activity also makes it a subject of interest in research aimed at elucidating the complex interactions within the central nervous system.


Lofepramine hydrochloride (CAS 26786-32-3) References

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  3. Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography-electrospray tandem mass spectrometry.  |  Hilton, MJ. and Thomas, KV. 2003. J Chromatogr A. 1015: 129-41. PMID: 14570326
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  7. Preadmission use of SSRIs alone or in combination with NSAIDs and 30-day mortality after peptic ulcer bleeding.  |  Gasse, C., et al. 2009. Scand J Gastroenterol. 44: 1288-95. PMID: 19891579
  8. Antihypertensive treatment as a possible cause of stroke in the elderly.  |  Jansen, PA., et al. 1986. Age Ageing. 15: 129-38. PMID: 3526836
  9. Atrial fibrillation and stroke in elderly hospitalized patients.  |  Treseder, AS., et al. 1986. Age Ageing. 15: 89-92. PMID: 3962763
  10. Effects of phenothiazines and dibenzazepines on axonal transport and microtubule assembly in vitro.  |  Ekström, P., et al. 1982. Acta Physiol Scand. 116: 121-5. PMID: 6188323
  11. Actions of lofepramine, a new tricyclic antidepressant, and desipramine on electrophysiological and mechanical parameters of guinea pig atrial and papillary muscles.  |  Arlock, P. 1981. Acta Pharmacol Toxicol (Copenh). 49: 248-58. PMID: 7342685
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lofepramine hydrochloride, 5 mg

sc-255256
5 mg
$171.00