LOC729825 Antibody (A-11): sc-390882

LOC729825 Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects LOC729825 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LOC729825 (A-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LOC729825 protein is located on chromosome 13, which is significant as this chromosome harbors key tumor suppressor genes, including BRCA2 and RB1, both of which play critical roles in cancer prevention. RB1 gene encodes a vital tumor suppressor protein that regulates the cell cycle, and its dysfunction can lead to uncontrolled cell proliferation, contributing to various cancers, including retinoblastoma. LOC729825 presence in this genomic context suggests potential important regulatory functions, possibly influencing tumorigenesis or other cellular processes. Chromosome 13 is also associated with developmental disorders when altered, such as trisomy 13, which can lead to severe health complications. LOC729825 gene product is currently provisionally designated LOC729825, pending further characterization to elucidate its specific biological roles and interactions.

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LOC729825 Antibody (A-11) References:

1. The DNA sequence and analysis of human chromosome 13.  |  Dunham, A., et al. 2004. Nature. 428: 522-8. PMID: 15057823
2. A new gene for Tourette's syndrome: a window into causal mechanisms?  |  Grados, MA. and Walkup, JT. 2006. Trends Genet. 22: 291-3. PMID: 16678301
3. RB and cell cycle progression.  |  Giacinti, C. and Giordano, A. 2006. Oncogene. 25: 5220-7. PMID: 16936740
4. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome.  |  Deng, H., et al. 2006. Acta Neurol Scand. 114: 400-2. PMID: 17083340
5. Non-disjunction of chromosome 13.  |  Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
6. Variable expressivity in Patau syndrome is not all related to trisomy 13 mosaicism.  |  Hsu, HF. and Hou, JW. 2007. Am J Med Genet A. 143A: 1739-48. PMID: 17603803
7. The origin of trisomy 13.  |  Hall, HE., et al. 2007. Am J Med Genet A. 143A: 2242-8. PMID: 17853475
8. Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.  |  Hassler, M., et al. 2007. Mol Cell. 28: 371-85. PMID: 17996702
9. BRCA2: a universal recombinase regulator.  |  Thorslund, T. and West, SC. 2007. Oncogene. 26: 7720-30. PMID: 18066084
10. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.  |  Hu, Z., et al. 2011. Nat Genet. 43: 792-6. PMID: 21725308
11. The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression.  |  Shao, L., et al. 2019. Genome Biol. 20: 103. PMID: 31126313
12. TNFRSF19 within the 13q12.12 Risk Locus Functions as a Lung Cancer Suppressor by Binding Wnt3a to Inhibit Wnt/β-Catenin Signaling.  |  Zuo, X., et al. 2024. Mol Cancer Res. 22: 227-239. PMID: 38047807

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LOC729825 Antibody (A-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LOC729825 Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LOC729825 Antibody (A-11) Specifications

Alternate Product Name: LOC729825

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 15-42

Epitope Target: LOC729825

Epitope Species: human

Product Reactivity/Detection: LOC729825

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LOC729825 Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin