LOC728213 Antibody (D-6): sc-376892

LOC728213 Antibody (D-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects LOC728213 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LOC728213 antibody (D-6) is available as the non-conjugated form. LOC728213 protein is located on chromosome 13, which is significant due to its association with several critical genes, including tumor suppressor genes like BRCA2 and RB1. RB1 gene encodes a vital tumor suppressor protein that plays a crucial role in regulating the cell cycle, and dysfunction can lead to uncontrolled cell proliferation, contributing to various cancers, including retinoblastoma. LOC728213 protein′s importance lies in potential involvement in cellular processes that may influence tumorigenesis, making LOC728213 (D-6) antibody a valuable target for research in cancer biology. Additionally, chromosome 13 harbors genes associated with developmental disorders, and abnormalities such as trisomy 13 can lead to severe developmental issues and increased mortality rates. LOC728213 gene product has been provisionally designated LOC728213 pending further characterization, highlighting the need for continued research to elucidate specific functions and interactions within the cellular environment.

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LOC728213 Antibody (D-6) References:

1. The DNA sequence and analysis of human chromosome 13.  |  Dunham, A., et al. 2004. Nature. 428: 522-8. PMID: 15057823
2. A new gene for Tourette's syndrome: a window into causal mechanisms?  |  Grados, MA. and Walkup, JT. 2006. Trends Genet. 22: 291-3. PMID: 16678301
3. RB and cell cycle progression.  |  Giacinti, C. and Giordano, A. 2006. Oncogene. 25: 5220-7. PMID: 16936740
4. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome.  |  Deng, H., et al. 2006. Acta Neurol Scand. 114: 400-2. PMID: 17083340
5. Non-disjunction of chromosome 13.  |  Bugge, M., et al. 2007. Hum Mol Genet. 16: 2004-10. PMID: 17584770
6. Variable expressivity in Patau syndrome is not all related to trisomy 13 mosaicism.  |  Hsu, HF. and Hou, JW. 2007. Am J Med Genet A. 143A: 1739-48. PMID: 17603803
7. The origin of trisomy 13.  |  Hall, HE., et al. 2007. Am J Med Genet A. 143A: 2242-8. PMID: 17853475
8. Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.  |  Hassler, M., et al. 2007. Mol Cell. 28: 371-85. PMID: 17996702
9. BRCA2: a universal recombinase regulator.  |  Thorslund, T. and West, SC. 2007. Oncogene. 26: 7720-30. PMID: 18066084

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LOC728213 Antibody (D-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LOC728213 Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LOC728213 Antibody (D-6) Specifications

Alternate Product Name: LOC728213

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 101-141

Epitope Target: LOC728213

Epitope Species: human

Product Reactivity/Detection: LOC728213

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LOC728213 Antibody (D-6): P: Blocking Peptide